Demonstration of two new endogenous "benzodiazepine-like" compounds from brain

Psychiatry Research
P J MarangosP Skolnick

Abstract

The recent report that purines are competitive inhibitors of specific [3H] diazepam binding to brain membranes has prompted further work concerning the characterization of possible endogenous ligands for the benzodiazepine receptor. In this report, two previously undescribed fractions capable of apparent competitive inhibition of [3H] diazepam binding are reported. Both factors are heat stable and resistant to proteolytic degradation. The larger factor (approximately 700 to 30,000 daltons) is present only in brain and pituitary. The smaller factor (500 to 600 daltons) is found in pituitary, liver, and muscle, but the highest levels are found in brain.

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T Asano, S Spector
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P SkolnickS Paul
Feb 26, 1979·Life Sciences·P J MarangosP Skolnick
Jun 1, 1978·European Journal of Pharmacology·M KarobathG Schönbeck
Apr 21, 1977·Nature·R F Squires, C Brastrup

Citations

Jan 1, 1981·Psychopharmacology·P J MarangosP Skolnick
Nov 1, 1991·Neurochemical Research·H KawasakiM Fukahori
Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·L G DavisD Reker
May 1, 1984·Peptides·J DeckertH Przuntek
Jan 1, 1983·Neurochemistry International·M Hamon, P Soubrié
Jan 1, 1982·Neuropharmacology·J N CrawleyF K Goodwin
Jan 1, 1981·Medicinal Research Reviews·P Skolnick, S Paul
Feb 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·G A Hibbert, M Chan

Related Concepts

Metazoa
Benzodiazepines
Brain Chemistry
Bos indicus
Liver
Myocardium
Pituitary Stalk
Receptors, Drug
Anti-Anxiety Effect
In Vitro [Publication Type]

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