PMID: 6109557Oct 1, 1980Paper

Demonstration with monoclonal antibody of the glycoprotein nature of Thy-1.2 alloantigen

Canadian Journal of Biochemistry
M LetarteP Lake

Abstract

Thy-1 antigen present in large amounts on the brain and thymus of mice, exists in two allelic forms, either Thy-1.1 or Thy-1.2. Previous results have shown that Thy-1.1 alloantigen is expressed on a glycoprotein of molecular weight 25 000, therefore referred to as the Thy-1 glycoprotein. However the presence of Thy-1.2 alloantigen on the purified Thy-1 glycoprotein could not be established unequivocally. The present paper demonstrates that Thy-1.2 alloantigen, identified by F7D5 monoclonal antibody, is localized on the Thy-1 glycoprotein. The limited neutralization by the glycoprotein of the reactivity of AKR anti-C3H allosera to thymocytes is explained by the fact that the antiserum contains antibodies to determinants other than Thy-1.2. The alloantisera are shown to react with viral proteins encoded for by endogenous murine leukemia virus and expressed at the surface of Friend cells and thymocytes.

Citations

Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A A Brian
Dec 29, 2007·Immunological Investigations·Joseph J SkitzkiSharon S Evans

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