PMID: 6411474Apr 1, 1983Paper

Demyelination and disturbed metabolism of pyruvate: a case report

European Journal of Pediatrics
R C SengersH J ter Laak

Abstract

A patient with demyelination is described. Lactate levels were elevated in serum, urine, and cerebrospinal fluid. A decreased pyruvate oxidation rate due to a pyruvate dehydrogenase complex deficiency was demonstrated in muscle and cultured fibroblasts. In muscle mitochondria no structural abnormalities were seen. The clinical course was progressive and the patient died at the age of 6 months.

Citations

Jan 1, 1991·Pediatric Radiology·K A HauseggerE Justich
Jan 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·H L van LaackC M Kerkhof
Apr 13, 2004·Arthritis and Rheumatism·Kristen JohnsonRobert Terkeltaub
Nov 1, 1989·Environmental Health Perspectives·R L Wershaw
Feb 1, 1984·European Journal of Pediatrics·R C SengersJ M Trijbels

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