Demyelination and early remyelination in experimental allergic encephalomyelitis passively transferred with myelin basic protein-sensitized lymphocytes in the Lewis rat.

Journal of Neuroimmunology
M P PenderD O Willenborg

Abstract

Histological studies were performed on Lewis rats with experimental allergic encephalomyelitis (EAE) passively transferred by myelin basic protein (MBP)-sensitized syngeneic spleen cells in order to determine the relationship between demyelination and neurological signs. Neither inflammation nor demyelination was present on the day prior to the onset of neurological signs but both were present in the spinal roots and spinal cord on the day of onset of tail weakness (4 days after passive transfer). Demyelination and the neurological signs both increased over the next 48 h. There was evidence that the caudal roots were more severely affected than the rostral roots. The peripheral nerves were spared. Demyelination in the spinal cord was concentrated in the dorsal root entry and ventral root exit zones. The initial stages of repair of demyelinated spinal root fibres by Schwann cells were observed on the earliest day that clinical recovery commenced (day 7). At this time some demyelinated fibres were closely associated with debris-free Schwann cells, and occasional fibres were completely invested by 1-2 layers of Schwann cell cytoplasm. Remyelination (compact myelin lamellae formation) by Schwann cells was first observed in the spin...Continue Reading

References

Oct 1, 1986·Journal of the Neurological Sciences·M P Pender
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Nov 1, 1985·Journal of Neuroscience Methods·M P Pender
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Citations

Jul 1, 1991·Journal of the Neurological Sciences·M P PenderJ F Kerr
Aug 1, 1992·Annals of Neurology·K VassH Lassmann
May 1, 1993·Annals of Neurology·M P Pender
May 1, 1993·Annals of Neurology·S PrzedborskiU Muthane

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