Demystifying ethnic/sex differences in kidney function: is the difference in (estimating) glomerular filtration rate or in serum creatinine concentration?

Clinica Chimica Acta; International Journal of Clinical Chemistry
Hans PottelFrank Martens

Abstract

The recent evaluation of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating the glomerular filtration rate (GFR) in multiple ethnicities has raised the question on how well this equation performs for African-American and Asian subjects. There is no doubt that serum creatinine (Scr) concentration differs between ethnicities and sexes. We show that creatinine-based equations for white populations may be inaccurate for estimating GFR in other ethnic/gender groups, especially in populations from Asia. This study presents a mathematical analysis of the CKD-EPI-equation complemented with a literature review of median and reference values for IDMS-standardized Scr-concentrations for multiple ethnicities. The study shows that at equal eGFR-CKD-EPI-values, the ratio of Scr between females and males equals 0.79 and between other ethnicities/sexes and white males is constant too. From this information, it is possible to calculate mean Scr-values that correspond very well with literature values directly obtained from Scr-distributions in healthy white males and females and in black males, but the discrepancy is larger for other populations. Our results confirm the criticism that has been raised for usin...Continue Reading

References

Dec 18, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C A JonesL Y Agodoa
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Jun 30, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·P RustadA Uldall
Jun 9, 2006·The New England Journal of Medicine·Lesley A StevensAndrew S Levey
Jan 19, 2008·Clinical Chemistry·Ferruccio CeriottiUNKNOWN IFCC Committee on Reference Intervals and Decision Limits (C-RIDL)
Jul 16, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hans PottelFrank Martens
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
May 26, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andrew D Rule, Boon Wee Teo
Oct 7, 2009·Clinical and Experimental Nephrology·Yoichi KakutaMasaru Horio
Apr 27, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaru HorioSeiichi Matsuo
May 27, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hans PottelFrank Martens
Jul 6, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ying-Chun MaHai-Yan Wang
Feb 18, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jan A J G van den BrandJack F M Wetzels
Aug 16, 2011·Kidney International·Pierre DelanayeAndrew D Rule
Jan 19, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Hans PottelFrank Martens

❮ Previous
Next ❯

Citations

Sep 21, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Liesbeth HosteHans Pottel
Mar 5, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hans PottelPierre Delanaye
Apr 10, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Nikki Rink, Michael Zappitelli
Aug 28, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giuseppe Lippi, Gianfranco Cervellin
Oct 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eric YayoPierre Delanaye
Sep 6, 2018·Journal of Clinical Pharmacology·Ryan L Crass, Manjunath P Pai
Jun 5, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Pierre Delanaye, Etienne Cavalier
Dec 8, 2016·European Journal of Endocrinology·Layal ChakerRobin P Peeters
Dec 13, 2016·Nature Reviews. Nephrology·Richard J GlassockPierre Delanaye
Aug 31, 2021·Current Opinion in Nephrology and Hypertension·Pierre DelanayeHans Pottel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved