Denatured globular protein and bile salt-coated nanoparticles for poorly water-soluble drugs: Penetration across the intestinal epithelial barrier into the circulation system and enhanced oral bioavailability

International Journal of Pharmaceutics
Wei HeLifang Yin

Abstract

Oral drug delivery is the most preferred route for patients; however, the low solubility of drugs and the resultant poor absorption compromise the benefits of oral administration. On the other hand, for years, the overwhelmingly accepted mechanism for enhanced oral absorption using lipid nanocarriers was based on the process of lipid digestion and drug solubilization in the small intestine. Few reports indicated that other bypass pathways are involved in drug absorption in the gastrointestinal tract (GIT) for oral delivery of nanocarriers. Herein, we report a new nanoemulsion system with a denatured globular protein with a diameter of 30 nm, soybean protein isolates (SPI), and bile salt as emulsifiers, aiming to enhance the absorption of insoluble drugs and explore other pathways for absorption. A BCS class II drug, fenofibrate (FB), was used as the model drug. The SPI and bile salt-coated Ns with a diameter of approximately 150 nm were prepared via a high-pressure homogenizing procedure. Interestingly, the present Ns could be converted to solid dosage form using fluid-bed coating technology, maintaining a nanoscale size. Most importantly, in a model of in situ rat intestinal perfusion, Ns could penetrate across the intestinal ...Continue Reading

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Dec 23, 2014·International Journal of Pharmaceutics·Wei HeLifang Yin

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Citations

May 11, 2016·Pharmaceutical Research·Zhiqiang TianWei Wu
Jun 23, 2016·Pharmaceutical Biology·Kaiyou WangJixiao Lang
Aug 11, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yixiang HuangGang Wang
Aug 22, 2017·Therapeutic Delivery·Chulhun ParkBeom-Jin Lee
Nov 22, 2019·Pharmaceutical Biology·Jing LiuYing Li
Sep 4, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yun ZhouGang Dong
Feb 7, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wei HeLifang Yin
Jul 28, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Feiyang Deng, You Han Bae

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