Dendrimer-like alpha-d-glucan nanoparticles activate dendritic cells and are effective vaccine adjuvants

Journal of Controlled Release : Official Journal of the Controlled Release Society
Fangjia LuHarm HogenEsch

Abstract

The use of nanoparticles for delivery of vaccine antigens and as vaccine adjuvants is appealing because their size allows efficient uptake by dendritic cells and their biological properties can be tailored to the desired function. Here, we report the effect of chemically modified phytoglycogen, a dendrimer-like α-d-glucan nanoparticle, on dendritic cells in vitro, and the utility of this type of nanoparticle as a vaccine adjuvant in vivo. The modified phytoglycogen nanoparticle, termed Nano-11, has a positive surface charge which enabled electrostatic adsorption of negatively charged protein antigens. The Nano-11-antigen complexes were efficiently phagocytized by dendritic cells. Nano-11 induced increased expression of costimulatory molecules and the secretion of IL-1β and IL-12p40 by dendritic cells. Intramuscular injection of Nano-11-antigen formulations induced a significantly enhanced immune response to two different protein antigens. Examination of the injection site revealed numerous monocytes and relatively few neutrophils at one day after injection. The inflammation had nearly completely disappeared by 2 weeks after injection. These studies indicate that Nano-11 is an effective vaccine delivery vehicle that significantl...Continue Reading

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Citations

Jan 31, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lanxia LiuGuilei Ma
May 23, 2015·Drug Discoveries & Therapeutics·Pingli Li, Fengshan Wang
Nov 3, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Maxim A ShevtsovGabriele Multhoff
Sep 12, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sean M GearyAliasger K Salem
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Jan 15, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Abbas HajizadeAyyoob Arpanaei
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Feb 11, 2020·Current Protein & Peptide Science·Jiemin WangDaxiong Xiang
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Aug 3, 2021·Chemical Reviews·Lu SuGuosong Chen
Aug 19, 2020·ACS Applied Materials & Interfaces·Quinn A BesfordFrancesca Cavalieri

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