Dendrimerlike mesoporous silica nanoparticles as pH-responsive nanocontainers for targeted drug delivery and bioimaging

ACS Applied Materials & Interfaces
Liangliang DaiKaiyong Cai

Abstract

In this work, we employed dendrimerlike mesoporous silica nanoparticles with hierarchical pores (HPSNs) to fabricate drug delivery system bioimaging and targeted tumor therapy in vivo. N,N-phenylenebis(salicylideneimine)dicarboxylic acid (Salphdc) was used both as the gatekeeper of HPSNs via pH-responsive coordination bonds between -COOH of Salphdc and In(3+) ions and as a fluorescence imaging agent. Folic acid was then conjugated to Salphdc as the targeting unit. The results revealed that the system could deliver model drug DOX to the tumor site with high efficiency and then cause cell apoptosis and tumor growth inhibition. Moreover, the conjugated Salphdc was proved to be a promising fluorescence probe for tracing distribution of the system in vivo. The study affords a potential nanoconainer for cancer therapy and biological imaging.

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Citations

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Nov 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Liangliang DaiKaiyong Cai
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Jan 1, 2016·Nanomaterials·Wen-Han ZhangXiao-Bing Zhang
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ganeshlenin Kandasamy, Dipak Maity

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