Jul 27, 2001

Dendrite development and target innervation of displaced retinal ganglion cells of the chick (Gallus gallus)

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
J Mey, V Johann

Abstract

The avian accessory optic system (AOS) processes visual signals of translational and rotational flowfields resulting from self-motion. It has been investigated extensively with physiological methods and, because of its anatomical distinction from other retinofugal projections, is well suited for the investigation of dendritic differentiation and axonal pathfinding. Displaced retinal ganglion cells (dRGC) constitute the retinal origin of the AOS. Since little is known about the time course of the development of this projection, we studied the dendritic differentiation of dRGC, their innervation of the nucleus of the basal optic root (nBOR) and the histological development of this target area. dRGC, visualized by retrograde 1,1'-dioctadecyl-3,3,3',3'-tetramethyl-indocarbocyanine perchlorate labeling, migrated into the inner nuclear layer of the retina and subsequently developed their characteristic dendritic morphology between E9 and E14. At this stage, dendrites were unistratified in the inner plexiform layer and displayed characteristic branches with 45-90 degrees angles. The frequency of dendritic branches increased from an average of 44 branches per cell at E9 to an average of 155 at E15. This phase was followed by a period o...Continue Reading

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Citations

Mentioned in this Paper

Optic Tract Structure
Biochemical Pathway
Entire Retina
Projections and Predictions
Muscle Innervation, Function
Science of Morphology
CALB2 gene
Neurons
Retinal Diseases
Calretinin

About this Paper

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