Dendrite elongation and dendritic branching are affected separately by different forms of intrinsic motoneuron excitability

Journal of Neurophysiology
Carsten DuchStefanie Ryglewski

Abstract

Dendrites are the fundamental determinant of neuronal wiring. Consequently dendritic defects are associated with numerous neurological diseases and mental retardation. Neuronal activity can have profound effects on dendritic structure, but the mechanisms controlling distinct aspects of dendritic architecture are not fully understood. We use the Drosophila genetic model system to test the effects of altered intrinsic excitability on postembryonic dendritic architecture development. Targeted dominant negative knock-downs of potassium channel subunits allow for selectively increasing the intrinsic excitability of a selected subset of motoneurons, whereas targeted expression of a genetically modified noninactivating potassium channel decrease intrinsic excitability in vivo. Both manipulations cause significant dendritic overgrowth, but by different mechanisms. Increased excitability causes increased dendritic branch formation, whereas decreased excitability causes increased dendritic branch elongation. Therefore dendritic branching and branch elongation are controlled by separate mechanisms that can be addressed selectively in vivo by different manipulations of neuronal intrinsic excitability.

References

Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P R Montague, M J Friedlander
Feb 15, 1994·The Journal of Comparative Neurology·J R Trimarchi, A M Schneiderman
Dec 1, 1995·Current Biology : CB·K DeisserothR W Tsien
Dec 1, 1995·Current Opinion in Neurobiology·J C Weeks, R B Levine
Dec 1, 1996·Current Biology : CB·B W Connors, W G Regehr
Jun 22, 2000·The Journal of Comparative Neurology·A MizrahiF Libersat
Oct 29, 2000·Science·M HäusserG J Stuart
Feb 13, 2001·Brain Research Bulletin·C ConsoulasR B Levine
Feb 17, 2001·Current Opinion in Neurobiology·H T Cline
Mar 6, 2002·Journal of Neurophysiology·C Duch, R B Levine
Jul 12, 2002·Nature·Christian LohmannRachel O L Wong
Jul 19, 2002·The Journal of Comparative Neurology·Frederic Libersat, Carsten Duch
Sep 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Toshihiro Kitamoto
Oct 3, 2002·Nature Reviews. Neuroscience·Rachel O L Wong, Anirvan Ghosh
Nov 28, 2002·The Journal of Comparative Neurology·Ethan K ScottLiqun Luo
Dec 4, 2002·Nature Reviews. Neuroscience·Anne E WestMichael E Greenberg
Apr 15, 2003·Journal of Neuroscience Research·Gabriele Spatkowski, Karl Schilling
May 15, 2003·Trends in Neurosciences·Fen-Biao Gao, Brigitte A Bogert
Sep 13, 2003·BMC Neuroscience·Subhabrata SanyalMani Ramaswami
Dec 31, 2003·The Journal of Biological Chemistry·Xiu Xia SunLeslie C Griffith
Feb 6, 2004·Nature Neuroscience·Cristopher M NiellStephen J Smith
Mar 30, 2004·Trends in Neurosciences·Susan Kim, Akira Chiba
Apr 6, 2004·Current Biology : CB·Susan J BroughtonRalph J Greenspan
Nov 5, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carsten Duch, Tim Mentel
Feb 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Timothy J MoscaHaig Keshishian
Apr 12, 2005·Cell Calcium·Christian Lohmann, Rachel O L Wong
Apr 12, 2005·Cell Calcium·Lori Redmond, Anirvan Ghosh
May 11, 2005·Journal of Neurobiology·Bradley M Cooke, Catherine S Woolley
Dec 17, 2005·Seminars in Cell & Developmental Biology·Matthias Landgraf, Stefan Thor
Jun 23, 2006·Nature Reviews. Neuroscience·Eve Marder, Jean-Marc Goaillard

❮ Previous
Next ❯

Citations

Mar 3, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Maurice MesekeCarsten Duch
Mar 10, 2012·Journal of Molecular Histology·Stefan WeigelAndreas Offenhäusser
Aug 11, 2012·Journal of Computational Neuroscience·Marco A Herrera-ValdezSharon Crook
Oct 13, 2011·Integrative and Comparative Biology·Katharina A Quinlan
Oct 16, 2009·Journal of Neurophysiology·Stefanie Ryglewski, Carsten Duch
Mar 10, 2009·Development·Megan M CortyWesley B Grueber
Mar 1, 2012·PloS One·Fernando VonhoffCarsten Duch
Dec 3, 2014·Proceedings of the National Academy of Sciences of the United States of America·Stefanie RyglewskiCarsten Duch
Dec 21, 2011·The Journal of Physiology·Stefanie RyglewskiCarsten Duch
May 14, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·S M ElBasiounyC J Heckman
Nov 20, 2015·Experimental Neurology·Anna E KingJames C Vickers
Dec 5, 2015·Frontiers in Computational Neuroscience·Sandra D Berger, Sharon M Crook
May 4, 2010·The Journal of Comparative Neurology·F Vonhoff, C Duch
Mar 27, 2016·Neurobiology of Disease·Alison A WilliamsCarsten Duch
Jul 22, 2016·PloS One·Alison A WilliamsCarsten Duch
May 10, 2017·Frontiers in Systems Neuroscience·Fernando Vonhoff, Haig Keshishian
Jul 4, 2020·Current Biology : CB·Anastasia HerreroMaría Fernanda Ceriani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.