Dendrite remodeling in development and disease

Development, Growth & Differentiation
Kazuo Emoto

Abstract

One of the most important features of neuronal function is the capacity to dynamically adapt in response to changes in the environment and neuronal activity. Among cellular elements that show this kind of plasticity are dendrites, the components that receive and process neuronal inputs. Dendrite remodeling occurs during normal development of the nervous system as well as in response to injury or diseases in the adult. In either case, selective stabilization and/or elimination of dendritic branches is likely important to shape dendritic arbors. Here I review examples of the phenomena and consider potential cellular and molecular mechanisms that underlie dendrite remodeling and how they might relate in development and disease.

References

Aug 7, 2012·Annals of Biomedical Engineering·Núria Royo-GasconWilliam Craelius
Jan 19, 2016·Frontiers in Neuroanatomy·Panagiotis BozelosPanayiota Poirazi
Nov 19, 2015·Radiation Research·Antiño R AllenJohn R Fike
Jul 14, 2019·Hippocampus·Rahul K Rathour, Rishikesh Narayanan

Citations

Jan 1, 1991·Annual Review of Neuroscience·L F Reichardt, K J Tomaselli
Oct 1, 1986·Annals of Neurology·L E BeckerF Chan
Mar 1, 1995·Journal of Neuropathology and Experimental Neurology·D ArmstrongR Trivedi
Jan 31, 1998·Science·G Y Wu, Hollis T Cline
Aug 11, 1998·Neuron·M J Berridge
Sep 28, 2000·Cerebral Cortex·W E Kaufmann, H W Moser
Feb 17, 2001·Current Opinion in Neurobiology·Hollis T Cline
Mar 29, 2001·Nature Neuroscience·E K Scott, Liqun Luo
Jul 4, 2001·Nature Reviews. Neuroscience·V W YongD R Edwards
Jul 12, 2002·Nature·Christian LohmannRachel O L Wong
Aug 6, 2002·Pediatric Neurology·Mario VuksićIvica Kostović
Oct 3, 2002·Nature Reviews. Neuroscience·Rachel O L Wong, Anirvan Ghosh
Oct 9, 2002·Nature Neuroscience·Hadley Wilson Horch, Lawrence C Katz
Dec 20, 2002·Nature·Jaime GrutzendlerWen-Biao Gan
Mar 29, 2003·Learning & Memory·Bai Lu
Jun 14, 2003·Brain : a Journal of Neurology·Jennifer E A WellsV Wee Yong
Jul 10, 2003·Current Opinion in Neurobiology·Freda D Miller, David R Kaplan
Sep 2, 2003·Journal of Neuroscience Research·Christina von GerttenAnn-Christin Sandberg Nordqvist
Apr 1, 2004·Birth Defects Research. Part C, Embryo Today : Reviews·Ivan PavlovHeikki Rauvala
Apr 16, 2004·Current Biology : CB·Ryan J WattsLiqun Luo
Jul 22, 2004·Journal of Neurobiology·Susan C Cook, Cara L Wellman
Oct 12, 2004·Neuron·Maria E Gallegos, Cornelia I Bargmann
Feb 16, 2005·Nature Neuroscience·Christian LohmannTobias Bonhoeffer

Related Concepts

Entire Nervous System
Neuronal Plasticity
Neuronal
Nervous System Structure
Dendrites
Nervous system DRUGS
Adapt (substance)
Nervous System Disorder
Human Activity Profile Test

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.