Aug 2, 2016

Dendrites of DG granule cells contribute to pattern separation by controlling sparsity

BioRxiv : the Preprint Server for Biology
Spyridon ChavlisPanayiota Poirazi


The hippocampus plays a key role in pattern separation, namely the process of transforming similar incoming information to highly dissimilar, non-overlapping representations. Sparse firing granule cells in the dentate gyrus have been proposed to undertake this computation, but little is known about which of their properties influence pattern separation. Dendritic atrophy and spine loss have been reported in diseases associated with pattern separation deficits, suggesting a possible role for dendrites in this phenomenon. To investigate whether and how the dendrites of granule cells contribute to pattern separation, we build a simplified, biologically relevant, computational model of the dentate gyrus. Our model suggests that the presence of granule cell dendrites is associated with high pattern separation efficiency while their atrophy leads to increased excitability and performance impairments that cannot be explained by input resistance changes. These impairments, however, can be rescued by a range of manipulations that restore network sparsity to control levels. Thus, our model suggests that the contribution of dendrites to pattern separation amounts to one of many ways for controlling sparsity. We provide a number of testabl...Continue Reading

  • References
  • Citations


  • We're still populating references for this paper, please check back later.
  • References
  • Citations


  • This paper may not have been cited yet.

Mentioned in this Paper

Genus Hippocampus
Structure of Hippocampal Formation
Entire Hippocampus
Metaplastic Cell Transformation
Dendritic Cells
Vertebral Column

About this Paper

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.