Dendritic arbor complexity and spine density changes after repetitive mild traumatic brain injury and neuroprotective treatments.

Brain Research
Whitney A RatliffB A Citron

Abstract

Traumatic brain injury has been described as the signature affliction of recent military conflicts and repetitive TBIs, particularly associated with military and athletic activities, typically result in more severe clinical effects. The majority of TBIs are mild, but they can result in long term cognitive deficits for which there is no effective treatment. One of the most significant deficits observed in TBI patients is memory loss, which suggests that TBI can induce pathological changes within the hippocampus. tert-butylhydroquinone (tBHQ) and pioglitazone activate the Nrf2 and PPAR-γ transcription factors, respectively, and both have been shown to be neuroprotective in model systems. We examined the morphological changes within the hippocampus following repetitive mild TBI and simultaneous treatment with both factors. We utilized a closed head injury mouse model with five injuries over 5 weeks. Our results showed marked morphological changes among the dendrites and dendritic spines of the neurons of the dentate gyrus of the hippocampus. We observed decreases in overall dendritic length, as well as in the quantity and density of dendritic spines. Our treatment partially ameliorated these effects, suggesting that the Nrf2 and P...Continue Reading

References

Sep 15, 1999·JAMA : the Journal of the American Medical Association·J W Powell, K D Barber-Foss
Nov 20, 2003·JAMA : the Journal of the American Medical Association·Michael McCreaJames P Kelly
May 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chi-Cheng WuFloyd E Bloom
Jul 12, 2005·Journal of Neurotrauma·S W ScheffC Brackney
Apr 28, 2006·Current Opinion in Psychiatry·Grant L Iverson
Jun 20, 2006·Neuroscience and Behavioral Physiology·V V SemchenkoA S Khizhnyak
Nov 24, 2006·The Journal of Head Trauma Rehabilitation·Wesley Rutland-BrownYongli Lily Xi
Jan 24, 2007·Journal of Neuroscience Research·David TweedieNigel H Greig
Jul 14, 2007·Neurological Research·José A RafolsChristian W Kreipke
Feb 1, 2008·The New England Journal of Medicine·Charles W HogeCarl A Castro
Jan 23, 2009·The Journal of Head Trauma Rehabilitation·Heidi TerrioDeborah Warden
Jun 25, 2009·Seminars in Neurology·Jeffrey Nicholl, W Curt LaFrance
Jan 22, 2013·The International Journal of Neuropsychopharmacology·Seong S ShimRonald F Mervis
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michele FerranteGiorgio A Ascoli
Jun 2, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Eric M CasellaP David Adelson
Dec 6, 2014·Behavioural Brain Research·Akiko Sheala ShingoToshio Murase
Jan 13, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kristina PilipovićGordana Župan
Mar 10, 2015·Molecular and Cellular Neurosciences·Raquel C Gardner, Kristine Yaffe
Nov 10, 2016·Behavioural Brain Research·Bridgette D SempleTerence J O'Brien
Jul 14, 2017·Journal of Neurotrauma·Jessica N SaykallyBruce A Citron
Apr 16, 2020·Journal of Neurotrauma·Whitney A RatliffBruce A Citron

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.