Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine.

Surgery Today
Satoshi HagiwaraTakayuki Noguchi

Abstract

Recent studies have increased our understanding of the important role that the immune system plays in ischemia-reperfusion (I/R) injury. Although dendritic cells (DCs) are important regulators of intestinal immunity, their role in the response to intestinal I/R injury is not well understood. The aim of this study was to determine whether I/R injury affects DC infiltration into the intestinal barrier. Wistar rats were subjected to I/R injury or a sham operation. Dendritic cells were visualized by immunohistochemistry, and after 12 h of reperfusion protein levels for nucleotide-binding oligomerization domain protein 2 (NOD2), high-mobility group box 1 (HMGB1), and Toll-like receptor 4 (TLR4) were assayed by Western blotting. The number of DCs increased at the small intestine barrier in response to intestinal I/R. A Western blot analysis of small intestinal tissue revealed that levels of NOD2, HMGB1, and TLR4 protein increased in rats subjected to I/R injury in comparison to control rats. These results suggest that intestinal I/R increases the infiltration of DCs into the small intestine, thus potentially involving the upregulation of NOD2, HMGB1, and TLR4. Therefore, intestinal I/R might activate DCs through NOD2 and HMGB1.

References

Apr 1, 1998·Nature·J Banchereau, R M Steinman
Dec 8, 1998·European Journal of Immunology·V VerhasseltF Willems
Jul 10, 1999·Science·H WangK J Tracey
Nov 5, 1999·Nature Medicine·S GallucciP Matzinger
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Aug 22, 2000·The Journal of Experimental Medicine·U AnderssonK J Tracey
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·H WangK J Tracey
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tim G A M WolfsCornelis van 't Veer
Feb 28, 2002·Free Radical Biology & Medicine·Charles J J AldermanDavid R Katz
Nov 18, 2003·Immunological Reviews·Adrian E Morelli, Angus W Thomson
Dec 9, 2003·The Journal of Biological Chemistry·Jong Sung ParkEdward Abraham
Apr 10, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Katherine A BarsnessRobert C McIntyre
Oct 16, 2004·Digestive Diseases and Sciences·Ismail Hameed MallickAlexander M Seifalian
Mar 30, 2005·The Journal of Experimental Medicine·Allan TsungTimothy R Billiar
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·George VladNicole Suciu-Foca
Nov 12, 2005·American Journal of Physiology. Cell Physiology·Shiguang LiuMitchell P Fink
Apr 28, 2006·Journal of Leukocyte Biology·Maria FotiPaola Ricciardi-Castagnoli
Jun 16, 2006·Inflammatory Bowel Diseases·Manuel A SilvaMary H Perdue
Oct 26, 2006·Journal of Leukocyte Biology·Allan TsungTimothy R Billiar
Nov 15, 2006·Current Pharmaceutical Design·H Takada, A Uehara
Mar 24, 2007·Annual Review of Immunology·Akiko Iwasaki
Nov 23, 2007·Biochemical Society Transactions·L Le BourhisS E Girardin
Dec 28, 2007·Journal of Leukocyte Biology·Steven C GribarDavid J Hackam
Mar 1, 2008·Surgery Today·Cevdet Ugur KoçogullariHikmet Koçak
Jun 25, 2008·Circulation·Martin AndrassyAngelika Bierhaus

❮ Previous
Next ❯

Citations

Sep 7, 2012·The Journal of Pathology·Laura CampbellMatthew J Hardman
Jul 11, 2014·Molecular Aspects of Medicine·Rui KangDaolin Tang
May 24, 2011·International Immunopharmacology·Qing LinShao Bo Su
Feb 21, 2019·Journal of Cellular and Molecular Medicine·Jiyang XueQifeng Zhao
Mar 2, 2013·Current Opinion in Organ Transplantation·Kaatje LenaertsSteven W M Olde Damink
Jan 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Diana ČepcováDiana Vavrincová-Yaghi
Mar 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jun WangGuosheng Wu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.