Dendritic cell-based multi-epitope immunotherapy of hormone-refractory prostate carcinoma

Cancer Immunology, Immunotherapy : CII
Ying Waeckerle-MenSilke Gillessen

Abstract

Dendritic cell (DC)-based immunotherapy is a promising approach to augment tumor antigen-specific T cell responses in cancer patients. However, tumor escape with down-regulation or complete loss of target antigens may limit the susceptibility of tumor cells to the immune attack. Concomitant generation of T cell responses against several immunodominant antigens may circumvent this potential drawback. In this trial, we determined the immunostimulatory capacity of autologous DC pulsed with multiple T cell epitopes derived from four different prostate-specific antigens in patients with advanced hormone-refractory prostate cancer. Autologous DC of HLA-A*0201(+) patients with hormone-refractory prostate cancer were loaded with antigenic peptides derived from prostate stem cell antigen (PSCA(14-22)), prostatic acid phosphatase (PAP(299-307)), prostate-specific membrane antigen (PSMA(4-12)), and prostate-specific antigen (PSA(154-163)). DC were intradermally applied six times at biweekly intervals followed-in the case of an enhanced immune response-by monthly booster injections. Immune monitoring during the time of ongoing vaccinations (12-59 weeks) included ex vivo ELISPOT measurements, MHC tetramer analysis and in vitro cytotoxicity ...Continue Reading

References

Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·A F OchsenbeinR M Zinkernagel
Jul 1, 1999·The Prostate·B A TjoaG P Murphy
Dec 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E J SmallF H Valone
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L FongE G Engleman
May 11, 2002·Nature Reviews. Immunology·Drew M Pardoll
May 11, 2002·Nature Reviews. Immunology·Susan M KaechRaft Ahmed
Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Mar 19, 2003·Advances in Cancer Research·Mary A Markiewicz, W Martin Kast
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert H VonderheideLee M Nadler
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Markus Y Mapara, Megan Sykes
Mar 23, 2004·Annual Review of Immunology·Federica SallustoAntonio Lanzavecchia
May 4, 2004·Nature Medicine·Carl G FigdorCornelis J M Melief
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael R BettsRichard A Koup
Jun 16, 2004·Cancer Immunology, Immunotherapy : CII·Murrium AhmadSelman A Ali
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Oct 8, 2004·The New England Journal of Medicine·Daniel P PetrylakE David Crawford
Nov 13, 2004·The Journal of Urology·Haakon RagdeBenjamin A Tjoa
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zhen SuJohannes Vieweg
May 17, 2005·Immunity·David J ZammitLeo Lefrançois

❮ Previous
Next ❯

Citations

Apr 10, 2012·Archivum Immunologiae Et Therapiae Experimentalis·Ammad Ahmad FarooqiSadia Rashid
Jun 4, 2008·Der Urologe. Ausg. A·D EngelerH-P Schmid
Jun 23, 2009·Der Urologe. Ausg. A·M A ReiterA Haferkamp
Oct 13, 2006·Cancer Immunology, Immunotherapy : CII·Andrea MarrariLicia Rivoltini
Jun 21, 2011·Cancer Immunology, Immunotherapy : CII·Naomi L DunningRobert C Rees
Apr 11, 2007·Prostate Cancer and Prostatic Diseases·E Elkord
Apr 7, 2007·Current Opinion in Urology·Douglas G McNeel
Jul 31, 2010·Journal of Oncology·Claudia PapewalisMatthias Schott
May 27, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Norihisa SaekiXifeng Wu
Jan 1, 2009·Immunotherapy·Anna-Katharina Thomas-Kaskel, Hendrik Veelken
Jan 19, 2012·Clinical Medicine Insights. Oncology·Robert J Amato, Mika Stepankiw
Aug 3, 2012·Immunotherapy·Arpit BhargavaPradyumna Kumar Mishra
Nov 16, 2010·Clinical & Developmental Immunology·Hanka JähnischMarc Schmitz
Dec 17, 2014·Clinical & Translational Immunology·Vasso ApostolopoulosStamatis Vassilaros
Aug 3, 2007·Expert Review of Vaccines·Martijn S BijkerSjoerd H van der Burg
Dec 7, 2013·Expert Review of Anticancer Therapy·Xueling YangWei Tian
Nov 18, 2009·Expert Opinion on Biological Therapy·Mayer Fishman
Feb 26, 2016·International Immunopharmacology·Keqiang ChenShaobo Su
Mar 7, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ying Waeckerle-MenPål Johansen
Jun 20, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marc MuellerMarcus Groettrup
Apr 24, 2010·Seminars in Immunology·Daniel E Speiser, Pedro Romero
Mar 10, 2009·Trends in Endocrinology and Metabolism : TEM·Margret WuttkeMatthias Schott
Mar 20, 2015·Biological & Pharmaceutical Bulletin·Hai-Bo XiYu Li
Nov 11, 2008·Urologic Oncology·Todd J Lehrfeld, David I Lee
Oct 8, 2008·Cancer Letters·Adam B RaffW Martin Kast
Dec 7, 2007·European Urology·Andrea KiesslingMarc Schmitz
Apr 25, 2007·The Prostate·Elena N KlyushnenkovaRichard B Alexander
May 22, 2007·International Journal of Cancer. Journal International Du Cancer·Anna-Katharina Thomas-KaskelHendrik Veelken
Jan 6, 2011·International Journal of Cancer. Journal International Du Cancer·Marc MuellerMarcus Groettrup

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.