Dendritic cell-based therapies in the bench and the bedsides

Current Drug Targets. Inflammation and Allergy
Sk Md Fazle AkbarMorikazu Onji

Abstract

Antigen-presenting dendritic cells (DCs) represent trace population of leukocytes that are widely distributed over the whole body. DCs are regarded as inducer of antigen-specific adaptive immune responses. However, various types of functions of DCs are now exposing. In the steady-state, DCs induce immunogenic tolerance to self antigens and harmless entities and thus maintain normal homeostasis. On the other hand, in presence of non-self and dangerous entities, DCs play a cardinal role in the induction of innate immunity by producing type-1 interferons. DCs are also essential for the development of antigen-specific B-lymphocytes and plasma cells. Infection, depletion and dysfunction of DCs have been reported from patients with chronic microbial infections. Impaired functions of DCs have also been shown from patients with autoimmune diseases and allergic diseases. Patients with cancers also have phenotypic and functional impairment of DCs. These observations inspired optimism of using DC-based therapy for treating different pathological conditions. DC-based therapies showed excellent therapeutic potential in animal model of human diseases. The efficacy of DC-based therapy has not been properly evaluated in patients with different...Continue Reading

Citations

Apr 13, 2011·Hepatology International·Daniel GrimmHubert E Blum
Dec 14, 2004·Journal of Zhejiang University. Science. B·Morikazu Onji, Sk Md Fazle Akbar
Oct 13, 2009·Expert Review of Gastroenterology & Hepatology·Antonio Bertoletti, Adam Gehring
Oct 13, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Antonio Bertoletti, Adam Gehring
Aug 5, 2009·The Journal of Veterinary Medical Science·Fuminori MizukoshiHajime Tsujimoto

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