Dendritic cell-based vaccine efficacy: aiming for hot spots

Frontiers in Immunology
Gabriela Andrea Pizzurro, María Marcela Barrio

Abstract

Many approaches for cancer immunotherapy have targeted dendritic cells (DCs), directly or indirectly, for the induction of antitumor immune responses. DC-based vaccines have been developed using a wide variety of ex vivo DC culture conditions, antigen (Ag) source and loading strategies, maturation agents, and routes of vaccination. Adjuvants are used to activate innate immune cells at the vaccine injection site, to promote Ag transport to the draining lymph nodes (LNs) and to model adaptive immune responses. Despite years of effort, the effective induction of strong and durable antitumor T-cell responses in vaccinated patients remains a challenge. The study of vaccine interactions with other immune cells in the LNs and, more recently, in the injection site has opened new doors for understanding antitumor effector T-cell licensing and function. In this review, we will briefly discuss the relevant sites and up-to-date facts regarding possible targets for antitumor vaccine refinement. We will focus on the processes taking place at the injection site, adjuvant combinations and their role in DC-based vaccines, LN homing, and modeling vaccine-induced immune responses capable of controlling tumor growth and generating immune memory.

References

Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gudrun RatzingerNikolaus Romani
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc DauerAndreas Eigler
May 6, 2003·Nature Immunology·Philippe Bousso, Ellen Robey
Aug 20, 2003·The Journal of Experimental Medicine·Alfonso MartIn-FontechaFederica Sallusto
Jan 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mark J MillerIan Parker
Mar 16, 2004·Journal of Neuro-oncology·Ulrich HerrlingerMichael Weller
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew KaiserAlessandra Nardin
Sep 22, 2005·Immunology and Cell Biology·Alberto Pinzon-CharryJ Alejandro López
Apr 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Noelia Sánchez-SánchezJosé Luis Rodríguez-Fernández
Sep 16, 2006·Immunological Reviews·David H Munn, Andrew L Mellor
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mitchell H GraysonMichael J Holtzman
Jul 31, 2007·Nature Immunology·Stéphanie HuguesLuc Fetler
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Luis VenceHideki Ueno
Jun 14, 2008·Expert Opinion on Biological Therapy·Pauline VerdijkCarl G Figdor
Dec 5, 2009·Current Topics in Microbiology and Immunology·Peter ReichardtMatthias Gunzer
Feb 9, 2010·Immunity·Alexandre BoissonnasSebastian Amigorena
Mar 5, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eileen M HighamJianzhu Chen
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Debasish SenMichael D Cahalan
May 22, 2010·Seminars in Immunology·Thomas W Dubensky, Steven G Reed
Jun 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefani SprangerBernhard Frankenberger
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marij J P WeltersSjoerd H van der Burg
Jul 14, 2010·Nature Medicine·Donna L HerberDmitry I Gabrilovich
Aug 10, 2010·The Cancer Journal·Karolina PaluckaJacques Banchereau
Aug 10, 2010·The Cancer Journal·Sacha GnjaticNina Bhardwaj
Aug 31, 2010·Advanced Drug Delivery Reviews·M SrinivasC G Figdor
Oct 30, 2010·Immunity·Karolina PaluckaIra Mellman
Mar 8, 2011·Seminars in Immunology·Lélia Delamarre, Ira Mellman
Mar 29, 2011·European Journal of Cell Biology·Bernhard Frankenberger, Dolores J Schendel
Apr 12, 2011·Journal of Surgical Oncology·Rongxiu Zheng, Suyu Shu
May 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter DuewellMax Schnurr
Jul 1, 2011·Immunologic Research·Pawel KalinskiDavid L Bartlett
Jul 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Joost LesterhuisCarl G Figdor

❮ Previous
Next ❯

Citations

Aug 12, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Achim SchneebergerMarkus Mandler
Mar 5, 2016·Current Rheumatology Reports·Femke C C van Rhijn-BrouwerJacob M van Laar
Jul 23, 2015·Cancer Immunology, Immunotherapy : CII·Gabriela A PizzurroMaría M Barrio
May 11, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kuan-Yin ShenShih-Jen Liu
Oct 21, 2017·Therapeutic Advances in Gastroenterology·Hwi Young Kim, Joong-Won Park
Jul 3, 2018·Immunology·Luca Cassetta, Takanori Kitamura
Feb 9, 2019·Advanced Healthcare Materials·Yuta AndoKeyue Shen
Jan 13, 2016·World Journal of Gastroenterology : WJG·Maridi AertsHendrik Reynaert
Jun 7, 2019·Immunological Investigations·Nataša TešićUrban Švajger
Apr 20, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Mi ZhangHuasong Feng
Aug 21, 2018·Frontiers in Immunology·Manh-Cuong VoJe-Jung Lee
Feb 12, 2019·Frontiers in Immunology·Apriliana E R KartikasariMagdalena Plebanski
May 16, 2020·Theoretical Biology & Medical Modelling·Marco AlbrechtThomas Sauter
Sep 2, 2015·The Journal of Clinical Investigation·Shabnam Shalapour, Michael Karin
Mar 31, 2018·Frontiers in Immunology·Maarten VerstevenEva Lion
Dec 23, 2016·Frontiers in Oncology·Valérie DutoitPaul R Walker
Jun 16, 2019·Cancer Communications·Jean-François RossiZhao-Yang Lu
Apr 4, 2021·Cancer Discovery·Leire BejaranoJohanna A Joyce
Mar 14, 2021·Journal of Molecular Neuroscience : MN·Mohammadmahdi SabahiNima Rezaei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Related Papers

Critical Reviews in Immunology
Marius M StriogaVirgil Schijns
Current Topics in Microbiology and Immunology
T G Berger, E S Schultz
Handbook of Experimental Pharmacology
Stefano Maria SantiniMaria Ferrantini
© 2021 Meta ULC. All rights reserved