Dendritic cell-based vaccines for the therapy of experimental tumors

Immunotherapy
Elzbieta Pajtasz-Piasecka, Marie Indrová

Abstract

Dendritic cells (DCs) are believed to be the most potent antigen-presenting cells able to link the innate and adaptive immune systems. Many studies have focused on different immunotherapeutic approaches to applying DCs as tools to improve anticancer therapy. Although a number of investigations suggesting the benefit of DC-based vaccination during anticancer therapy have been reported, the general knowledge regarding the ultimate methods of DC-vaccine preparation is still unsatisfactory. In this article, the perspectives of DC-based anti-tumor immunotherapy and optimizing strategies of DC vaccination in humans in light of results obtained in mouse models are discussed.

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Citations

Aug 3, 2012·Immunotherapy·Arpit BhargavaPradyumna Kumar Mishra
Apr 9, 2011·Stem Cell Reviews and Reports·Peter McColganPaul Bentley
Dec 14, 2011·Expert Review of Vaccines·Delaram Doroud, Sima Rafati
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Oct 16, 2012·Journal of Drug Targeting·Arpit BhargavaPradyumna Kumar Mishra
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Jun 17, 2011·Immunobiology·Joanna RossowskaDanuta Duś
Mar 29, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adeel RehmanGeorge Miller

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