Dendritic cell-derived TNF-alpha is responsible for development of IL-10-producing CD4+ T cells

Cellular Immunology
Noriyuki HirataKazuya Iwabuchi

Abstract

Immature dendritic cells (DCs) appear to be involved in peripheral immune tolerance via induction of IL-10-producing CD4(+) T cells. We examined the role of TNF-alpha in generation of the IL-10-producing CD4(+) T cells by immature DCs. Immature bone marrow-derived DCs from wild type (WT) or TNF-alpha(-/-) mice were cocultured with CD4(+) T cells from OVA specific TCR transgenic mice (OT-II) in the presence of OVA(323-339) peptide. The WT DCs efficiently induced the antigen-specific IL-10-producing CD4(+) T cells, while the ability of the TNF-alpha(-/-) DCs to induce these CD4(+) T cells was considerably depressed. Addition of exogenous TNF-alpha recovered the impaired ability of the TNF-alpha(-/-) DCs to induce IL-10-producing T cells. However, no difference in this ability was observed between TNF-alpha(-/-) and WT DCs after their maturation by LPS. Thus, TNF-alpha appears to be critical for the generation of IL-10-producing CD4(+) T cells during the antigen presentation by immature DCs.

References

Feb 24, 2001·The Journal of Experimental Medicine·M V DhodapkarN Bhardwaj
Feb 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Sayuri YamazakiRalph M Steinman
Mar 22, 2007·Nature Immunology·Estelle BettelliVijay K Kuchroo
May 27, 2008·Nature Reviews. Immunology·Janine L Coombes, Fiona Powrie
Sep 19, 2008·Immunity·Yasmine Belkaid, Guillaume Oldenhove

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Citations

Apr 23, 2020·Animals : an Open Access Journal From MDPI·Vladimir Zmrhal, Petr Slama

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