Dendritic cell infiltration and prognosis of early stage breast cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Isabelle TreilleuxSerge Lebecque

Abstract

Although dendritic cells (DC) and T cells can infiltrate primary breast carcinoma, it remains unclear whether the immune response influences the clinical outcome. T lymphocytes and DC infiltration within primary tumors was investigated in 152 patients with invasive nonmetastatic breast cancer. CD1a, CD3, CD68, CD123, CD207/Langerin, and CD208/DC-LAMP expression was assessed with semiquantitative immunohistochemical analysis. Expression of chemokines involved in DC migration (MIP-3a/CCL20, MIP-3b/CCL19, and 6Ckine/CCL21) was also examined. The correlation between these markers and the characteristics of the tumors, as well as relapse-free and overall survival was analyzed. Significant prognostic parameters were then tested in a validation series. Infiltration by immature CD207/Langerin+ DC was found in a third of the cancers and did not correlate with clinicopathological data. Presence of mature CD208/DC-LAMP+ DC (56%) and CD3+ T cells (82%) strongly correlated with lymph node involvement and tumor grade. Among the chemokines analyzed, only the presence of MIP-3b/CCL19 in 57% of the tumors correlated with prolonged overall survival. CD123+ plasmacytoid DC (pDC) infiltrated 13% of the primary tumors. Their presence was strongly a...Continue Reading

References

May 1, 1991·Pathology, Research and Practice·A GianniniG Zampi
Jun 3, 1967·Lancet·F M Burnet
Jan 1, 1997·Advances in Cancer Research·M L Disis, M A Cheever
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Jun 25, 1998·Archives of Otolaryngology--head & Neck Surgery·S A GoldmanM T Lotze
Aug 17, 1999·Journal of Leukocyte Biology·B DuboisF Brière
Feb 9, 2000·The Journal of Experimental Medicine·R M SteinmanK Inaba
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S SharmaS M Dubinett
Jul 11, 2000·Archives of Pathology & Laboratory Medicine·P L FitzgibbonsS J Schnitt
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A P VicariC Caux
Mar 29, 2001·Nature Immunology·M J SmythJ A Trapani
Aug 18, 2001·Cell·J BanchereauG Schuler
Nov 2, 2001·Nature Medicine·L L Lanier
Dec 18, 2001·European Journal of Immunology·W ZouT J Curiel
Dec 19, 2001·The Journal of Pathology·Akitake SuzukiTakeshi Kasajima
Feb 6, 2002·The Journal of Experimental Medicine·Laurence Zitvogel
Mar 20, 2002·The Journal of Experimental Medicine·Michel Gilliet, Yong-Jun Liu
Mar 27, 2002·Nature Reviews. Immunology·Ken Shortman, Yong-Jun Liu
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Nov 15, 2002·The New England Journal of Medicine·Khandan KeyomarsiSarah S Bacus
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards

❮ Previous
Next ❯

Citations

Aug 23, 2006·Cancer Immunology, Immunotherapy : CII·Elizabeth M E VerdegaalSusanne Osanto
Feb 21, 2008·Cancer Immunology, Immunotherapy : CII·Raffaele Adolfo CalogeroFederica Cavallo
Sep 18, 2009·Cancer Immunology, Immunotherapy : CII·Sumiya IshigamiShoji Natsugoe
May 26, 2011·Seminars in Immunopathology·Antonella SistiguLaurence Zitvogel
Oct 4, 2006·Cancer Metastasis Reviews·A Ben-Baruch
Aug 25, 2007·Cancer Metastasis Reviews·James E TalmadgeEric Scholar
Jan 29, 2011·Cancer Metastasis Reviews·Catherine Sautès-FridmanMarie-Caroline Dieu-Nosjean
Feb 14, 2012·Targeted Oncology·Christine Ménétrier-CauxWeiping Zou
Mar 23, 2012·Nature Reviews. Cancer·Karolina Palucka, Jacques Banchereau
Jul 23, 2011·Nature Reviews. Immunology·Boris ReizisMichel Gilliet
Oct 7, 2008·Oncogene·N ChaputL Zitvogel
Jul 1, 2009·The Journal of Experimental Medicine·Wei CaoYong-Jun Liu
Jul 28, 2009·Human Gene Therapy·Robin J PrestwichRichard G Vile
Apr 29, 2008·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jon R InglefieldJohn P Vasilakos
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Clara UgoliniAntonio Toniolo
Apr 14, 2010·Journal of Immunotherapy·Sandra DemariaMichael T Lotze
Nov 26, 2013·The Cancer Journal·Karolina PaluckaJoyce O'Shaughnessy
Nov 21, 2007·Annals of the Rheumatic Diseases·Roger SutmullerGosse J Adema
Oct 3, 2008·The Journal of Clinical Investigation·Stephan RouxFrançois Ghiringhelli
Mar 26, 2011·The Journal of Clinical Investigation·Stephanie K WatkinsArthur A Hurwitz
Aug 16, 2011·The Journal of Clinical Investigation·Emilie MamessierDaniel Olive
Jan 19, 2012·The Journal of Clinical Investigation·Barbara DrobitsMaria Sibilia
Jul 25, 2009·PLoS Genetics·David F VincentLaurent Bartholin
Oct 9, 2013·Cancer Immunology, Immunotherapy : CII·Dmitriy W Gutkin, Michael R Shurin
Nov 15, 2012·Immunotherapy·Jurjen Tel, I Jolanda M de Vries
Dec 24, 2011·Cancer Immunology, Immunotherapy : CII·Jurjen TelI Jolanda M de Vries
Jul 6, 2014·Journal of Mammary Gland Biology and Neoplasia·Ashleigh UnsworthKara Britt
Aug 26, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yan-Hong NiYa-Yi Hou
Feb 5, 2009·Clinical & Developmental Immunology·Jorge Schettini, Pinku Mukherjee
Dec 20, 2005·Cancer Immunology, Immunotherapy : CII·Niels Schaft, Jan Dörrie
Aug 13, 2015·International Journal of Molecular Sciences·Xiaoyu LiaoWeihua Jia
Oct 5, 2013·Expert Review of Vaccines·Laura BracciFilippo Belardelli
May 1, 2007·Expert Review of Clinical Immunology·Silvia Della BellaMaria Luisa Villa
Dec 21, 2012·Expert Review of Anticancer Therapy·Leisha A Emens
Apr 25, 2014·Expert Review of Clinical Immunology·Ghaith BakdashJurjen Tel
Dec 25, 2012·Expert Review of Anticancer Therapy·Patrick J StiffMaureen L Drakes

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