Abstract
Inflammatory cells, such as dendritic cells, are considered to trigger the antitumoral immune response against tumors, such as testicular cancer. Male infertility associated with cancer may be due to endocrine or immunological factors. We investigated possible associations of antigen expression with dendritic cells, histiocytic cells and seminoma stage as well as with impaired spermatogenesis. From 1992 to 1999, 30 patients with seminoma underwent orchiectomy at our center, including 14 who underwent spermiography before orchiectomy. Streptavidin-biotin immunostaining was performed on paraffin -embedded tumor specimens using antibodies against protein S-100 for dendritic cells and CD68-KP1 antigen. Light infiltration by less than 20 dendritic cells and less than 103 CD68+ cells was associated with tumor size greater than 1.5 cm. in 75% and 80% of patients, respectively. Strong infiltration by greater than 20 dendritic cells and greater than 103 CD68+ cells was associated with negative lymph nodes in 86% of patients. Slight infiltration by dendritic cells was observed in 71% of patients with a sperm count of greater than 8.6 million per ml. and in 100% with more than 45% motile sperm (p not significant and 0.02, respectively). N...Continue Reading
References
Nov 24, 1977·The New England Journal of Medicine·R A VigerskyD L Loriaux
Apr 1, 1992·Human Pathology·Y Q WeiK F Liu
Jun 1, 1991·International Journal of Andrology·R S FosterJ P Donohue
Aug 15, 1989·Cancer·P V HansenP E Helkjaer
Feb 1, 1989·Cancer·K AmbeM Enjoji
Dec 1, 1983·British Journal of Urology·W F HendryM J Peckham
Nov 27, 1995·International Journal of Cancer. Journal International Du Cancer·C RadmayrM Thurnher
Sep 1, 1995·Urology·A AgarwalM Shekarriz
Jan 1, 1994·Annual Review of Immunology·T BoonA Van Pel
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·K InoueY Fujita
Jan 1, 1996·The Journal of Experimental Medicine·J W Young, K Inaba
Dec 1, 1995·International Journal of Andrology·K JahnukainenN E Skakkebaek
Jun 1, 1996·Immunology Today·J H PetersF Steinbach
Feb 1, 1997·Fertility and Sterility·O F PadronA Agarwal
Jan 1, 1997·Histopathology·A TorresJ Regadera
May 1, 1997·Human Pathology·V Wright-BrowneZ Estrov
Feb 10, 1998·Human Reproduction·S KlieschH M Behre
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E Rajpert-De MeytsN E Skakkebaek
Jun 9, 1998·Japanese Journal of Cancer Research : Gann·S KuwabaraK Hatakeyama
Jun 17, 1998·The Journal of Urology·A TroyD Hart
Jun 25, 1998·Archives of Otolaryngology--head & Neck Surgery·S A GoldmanM T Lotze
Feb 27, 1999·Urologia Internationalis·M ThurnherG Bartsch
Mar 10, 1999·British Journal of Cancer·E E HillenbrandB J Coventry
Jul 20, 1999·The Journal of Urology·T SchwaabM S Ernstoff