Dendritic cell synthesis of C3 is required for full T cell activation and development of a Th1 phenotype

The Journal of Immunology : Official Journal of the American Association of Immunologists
Qi PengWuding Zhou

Abstract

Previous studies have found that deficiency of complement component C3 is associated with reduced T cell responses in several disease models including viral infection, autoimmune disease, and transplantation. However, the underlying mechanism is unclear. In this study, we demonstrate that dendritic cells (DCs) are able to synthesize C3 and this synthesis is required for the capacity of DCs to stimulate alloreactive T cell responses in vitro and in vivo. Compared with C3-producing DCs, C3-nonproducing DCs exhibit reduced potency to stimulate an alloreactive T cell response, favor the polarization of CD4(+) T cells toward Th2 phenotype, and have regulatory T cell-driving capacity. In addition, priming mice with C3-deficient DCs compared with wild-type DCs led to delayed skin allograft rejection. Our findings that nonproduction of C3 by DCs significantly reduced T cell stimulation and impaired allograft rejection provide a potentially important explanation of how C3-deficient mice develop reduced T cell responses and of how C3-deficient donor kidney is protected from T cell-mediated graft rejection.

References

Aug 1, 1991·The Journal of Clinical Investigation·R A BrooimansM R Daha
Mar 1, 1990·Immunology Today·R I LechlerF H Bach
Aug 15, 1989·Journal of Immunological Methods·C W Van den BergP J Capel
Oct 1, 1996·Current Opinion in Immunology·T B StromA Bushell
Jul 1, 1995·Molecular Medicine Today·P A AndrewsS H Sacks
Oct 19, 1999·The Journal of Experimental Medicine·A F OchsenbeinR M Zinkernagel
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Mar 22, 2001·Kidney International·W ZhouS H Sacks
Apr 5, 2001·The New England Journal of Medicine·M J Walport
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M K LevingsM G Roncarolo
May 5, 2001·Immunity·R LechlerR M Steinman
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Jun 4, 2002·Nature Medicine·Julian R PrattSteven H Sacks
Jan 9, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·M SureshMatyas Sandor
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Jul 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Steven H Sacks, Wuding Zhou
Jul 23, 2003·The Journal of Experimental Medicine·Sayuri YamazakiRalph M Steinman
Sep 17, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ralph M Steinman
Jan 22, 2004·Current Opinion in Immunology·Caetano Reis e Sousa
Sep 30, 2004·Nature Immunology·Michael C Carroll
Oct 16, 2004·European Journal of Immunology·Dela Golshayan, Robert Lechler
Dec 21, 2004·Springer Seminars in Immunopathology·Kenneth L RockYan Shi
Dec 21, 2004·Springer Seminars in Immunopathology·Esther C de JongMartien L Kapsenberg
Oct 26, 2005·Nature Immunology·Karsten KretschmerHarald von Boehmer
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander Sasha KrupnickDaniel Kreisel

❮ Previous
Next ❯

Citations

Nov 28, 2007·Annual Review of Pathology·Lynn D CornellRobert B Colvin
Apr 15, 2008·Transplantation·Jeffrey DammanMarc A Seelen
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arije GhannamChristian Drouet
Sep 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vasile PavlovPeter S Heeger
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qi PengWuding Zhou
Dec 17, 2009·Clinical and Experimental Immunology·D A CoplandL B Nicholson
Mar 12, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jong Cheol JeongJaeseok Yang
May 26, 2012·Nature Reviews. Immunology·Steven H Sacks, Wuding Zhou
Aug 21, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Wojciech BłogowskiTeresa Starzyńska
May 28, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Taiping LiuWenyue Xu
Dec 10, 2013·Current Opinion in Organ Transplantation·Conrad A Farrar, Steven H Sacks
Nov 12, 2014·Immunology and Cell Biology·Anne S De GrootPaul M Knopf
May 26, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joong-Hyuk SheenPeter S Heeger
Sep 26, 2020·Frontiers in Immunology·Shuang GaoMing-Hui Zhao
Aug 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yumi NakayamaM Suresh
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rolf SpirigRobert Rieben
Sep 14, 2007·Immunological Reviews·Ramon Roozendaal, Michael C Carroll
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter N LalliPeter S Heeger
Dec 31, 2008·Infection and Immunity·Kileen L MershonDavid O Beenhouwer
Apr 2, 2009·Current Opinion in Organ Transplantation·Steven SacksWuding Zhou
Feb 6, 2013·The Journal of Experimental Medicine·Wing-hong KwanPeter S Heeger
May 16, 2012·The Journal of Clinical Investigation·Wing-Hong KwanPeter S Heeger
Jan 10, 2012·Circulation Research·David J MarchantBruce M McManus
Jan 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Lucie BaudinoMarina Botto
Nov 26, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J OchandoM Collin
Oct 27, 2016·Immunological Reviews·Pedro BerraondoRuben Pio
Jul 30, 2020·Journal of Immunology Research·Ulrike WernerBarbara Wollenberg
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A W Thomson, R L Fairchild
May 20, 2009·Pharmacogenomics·Gregory A PolandRobert M Jacobson
Jul 9, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihiro FukuokaLawrence B Schwartz
Jun 8, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A BradleyA D Kirk
May 12, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Tao LinSteven H Sacks
Aug 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lacey GunnJun Yan
Jun 16, 2015·Frontiers in Immunology·Nicolas S MerleLubka T Roumenina
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sudhir K YadavKouichi Ito
Dec 12, 2018·Journal of Leukocyte Biology·Mohammad Afzal Khan, Talal Shamma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.