Dendritic cell type-specific HIV-1 activation in effector T cells: implications for latent HIV-1 reservoir establishment

AIDS
Renée M van der SluisThijs van Montfort

Abstract

Latent HIV type I (HIV-1) infections can frequently occur in short-lived proliferating effector T lymphocytes. These latently infected cells could revert into resting T lymphocytes and thereby contribute to the establishment of the long-lived viral reservoir. Monocyte-derived dendritic cells can revert latency in effector T cells in vitro. Here we investigated the latency activation properties of tissue-specific immune cells, including a large panel of dendritic cell subsets, to explore in which body compartments effector T cells are most likely to maintain latent HIV-1 provirus and thus potentially contribute to the long-lived reservoir. Our results demonstrate that blood or genital tract dendritic cells do not activate latent provirus in effector T cells, whereas gut or lymphoid dendritic cells induce virus production from latently infected effector T cells in our in-vitro model for latency. Toll-like receptor 3-induced interferon production by myeloid dendritic cells abolished the dendritic cells' ability to induce viral gene expression. In this study, we show that HIV-1 provirus residing in effector T cells is activated from latency by tissue-specific dendritic cell subsets and other immune cells with remarkably different e...Continue Reading

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Citations

Apr 13, 2018·Journal of Virology·Simin D RezaeiPaul U Cameron
Jul 12, 2016·Nature Medicine·Steven G DeeksJerome Zack
Sep 13, 2017·AIDS Research and Therapy·Joshua PankracJamie F S Mann
Jan 8, 2020·Viruses·Jan KristoffRobbie B Mailliard
Feb 23, 2020·Cell Reports·Gilles DarcisAlexander O Pasternak

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