Dendritic cells activated by an anti-inflammatory agent induce CD4(+) T helper type 2 responses without impairing CD8(+) memory and effector cytotoxic T-lymphocyte responses.

Immunology
Yang WangDonald A Harn

Abstract

Prevalence of pro-inflammatory diseases is rising in developed country populations. The increase in these diseases has fuelled the search for new, immune suppressive, anti-inflammatory therapies, which do not impact, or minimally impact, CD4(+) and/or CD8(+) T-cell-mediated immunity. The goal of this study was to determine if antigen-presenting cells (APCs) activated by the anti-inflammatory oligosaccharide, lacto-N-fucopentaose III (LNFPIII), would have an impaired ability to drive CD4(+) T helper (Th) or CD8(+) memory and effector T-cell responses. To investigate this we activated splenic dendritic cells (SDCs) with LNFPIII and examined their ability to drive antigen-specific CD4(+) Th, and CD8(+) memory and cytotoxic T-cell (CTL) responses compared with lipopolysaccharide (LPS) -stimulated SDCs. The LNFPIII-activated SDCs had altered co-stimulatory molecule expression compared with LPS-stimulated SDCs, while the levels of SDC chemokines following activation by either compound were similar. LNFPIII-activated SDCs produced significantly lower levels of interleukin-12 but surprisingly higher levels of interleukin-6 than LPS-activated SDCs. Similar to previous studies using bone-marrow-derived DCs, LNFPIII-activated SDCs induced...Continue Reading

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Citations

Sep 24, 2013·BMC Complementary and Alternative Medicine·Shilpi SahaTanya Das
Oct 7, 2015·Journal of Neuroimmunology·Dante J Marciani
Jan 1, 2012·Bioscience of Microbiota, Food and Health·Masao GotoMotomitsu Kitaoka
Sep 11, 2019·The American Journal of Clinical Nutrition·Evelyn Jantscher-KrennMireille N M van Poppel
Mar 7, 2020·Frontiers in Immunology·Bing ZhengChaohong Liu
Jul 21, 2016·Current Environmental Health Reports·Christopher A LowryGraham A W Rook
Jan 9, 2019·Frontiers in Immunology·Matthew Lacorcia, Clarissa U Prazeres da Costa
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