Dendritic Cells and Their Role in Immunotherapy.

Frontiers in Immunology
Alycia GardnerBrian Ruffell

Abstract

Despite significant advances in the field of cancer immunotherapy, the majority of patients still do not benefit from treatment and must rely on traditional therapies. Dendritic cells have long been a focus of cancer immunotherapy due to their role in inducing protective adaptive immunity, but cancer vaccines have shown limited efficacy in the past. With the advent of immune checkpoint blockade and the ability to identify patient-specific neoantigens, new vaccines, and combinatorial therapies are being evaluated in the clinic. Dendritic cells are also emerging as critical regulators of the immune response within tumors. Understanding how to augment the function of these intratumoral dendritic cells could offer new approaches to enhance immunotherapy, in addition to improving the cytotoxic and targeted therapies that are partially dependent upon a robust immune response for their efficacy. Here we will discuss the role of specific dendritic cell subsets in regulating the anti-tumor immune response, as well as the current status of dendritic cell-based immunotherapies, in order to provide an overview for future lines of research and clinical trials.

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
imaging techniques
scRNA-seq
scRNAseq
xenograft

Clinical Trials Mentioned

NCT03410901
NCT03010176
NCT03789097
NCT01976585
NCT00045968
NCT01582672
NCT02950766
NCT03639714
NCT03953235
NCT04161755

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