Dendritic cells are equally distributed in intrauterine and tubal ectopic pregnancies

Fertility and Sterility
Birgit KempUlrike von Rango

Abstract

To examine different stages of dendritic cells (DCs) in intrauterine (IUPs) and viable tubal (VTPs) pregnancies to further elucidate mechanisms of fetomaternal tolerance and extravillous trophoblast invasion. Experimental study on patient-controlled material. University hospital. Seven women with normal IUPs and ten with VTPs in the first trimester. Suction curettage in IUP, laparoscopy in VTP. Immunohistochemistry for cytokeratin-7 (trophoblast), CD83 (mature DCs), DEC205 (activated but not fully mature DCs), DC-SIGN (immature macrophage-like DCs), and CD14 (macrophages) alone and in double staining. The numbers of CD83+ and DEC205+ cells were similarly low in IUP and VTP (0.83 and 0.44 cells/mm2; 2.28 and 2.96 cells/mm2). The number of DC-SIGN+ cells was higher, though without significant differences among the entities examined (57.5 and 47.4 cells/mm2). About two-thirds of DC-SIGN+ cells were also CD14+ in IUP and VTP. The almost equal distribution of CD83+, DEC205+, and DC-SIGN+ cells in IUP and VTP suggests analogue control mechanisms in intrauterine and extrauterine DC differentiation and a comparable role of these DCs for the development of fetomaternal tolerance.

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Citations

Jun 15, 2011·Current Opinion in Obstetrics & Gynecology·Jeremy K Brown, Andrew W Horne
Jan 10, 2013·Annual Review of Immunology·Adrian Erlebacher
Jun 7, 2011·Journal of Reproductive Immunology·Astrid Hammer
Jul 6, 2014·Journal of Immunology Research·Alicia Martínez-VareaAntonio Pellicer
Dec 3, 2016·Science China. Life Sciences·Binqing Fu, Haiming Wei
Jan 24, 2019·American Journal of Reproductive Immunology : AJRI·Xia WangPhilip C N Chiu
Aug 21, 2014·Endocrine Reviews·Birgit Gellersen, Jan J Brosens
Jun 13, 2020·International Reviews of Immunology·Xiaopeng LiBolan Yu
Jul 27, 2018·Histochemistry and Cell Biology·Gerit MoserBerthold Huppertz
Sep 18, 2020·Placenta·Orestis TsonisPanagiotis Kanavaros
Jun 26, 2021·Frontiers in Immunology·Pengfei ChenLisha Mou

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