PMID: 8976199Dec 1, 1996Paper

Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli

The Journal of Experimental Medicine
A S McWilliamP G Holt

Abstract

A key rate-limiting step in the adaptive immune response at peripheral challenge sites is the transmission of antigen signals to T cells in regional lymph nodes. Recent evidence suggests that specialized dendritic cells (DC) fulfill this surveillance function in the resting state, but their relatively slow turnover in most peripheral tissues brings into question their effectiveness in signaling the arrival of highly pathogenic sources of antigen which require immediate mobilization of the full range of host defenses for maintenance of homeostasis. However, the present report demonstrates that recruitment of a wave of DC into the respiratory tract mucosa is a universal feature of the acute cellular response to local challenge with bacterial, viral, and soluble protein antigens. Consistent with this finding, we also demonstrate that freshly isolated respiratory mucosal DC respond in vitro to a variety of CC chemokines as well as complementary cleavage products and N-formyl-methionyl-leucine-phenylalanine. This suggests that rapid amplification of specific antigen surveillance at peripheral challenge sites is an integral feature of the innate immune response at mucosal surfaces, and serves as an "early warning system" to alert the...Continue Reading

References

Jan 1, 1991·Annual Review of Immunology·R M Steinman
Nov 1, 1989·Research in Immunology·S Fossum
Jun 1, 1986·The Journal of Investigative Dermatology·H D ChenW K Silvers
Jan 1, 1983·Immunological Reviews·D W MasonM L Thomas
Apr 1, 1994·The Journal of Experimental Medicine·A S McWilliamP G Holt

❮ Previous
Next ❯

Citations

Oct 1, 1998·European Journal of Immunology·F SallustoA Lanzavecchia
Dec 4, 1998·Springer Seminars in Immunopathology·R Thomas
Oct 26, 2012·Inflammopharmacology·L L Ma, Paul M O'Byrne
Dec 29, 2005·Journal of Clinical Immunology·Peter DubskyA Karolina Palucka
Feb 16, 2006·Current Allergy and Asthma Reports·David Proud
Oct 6, 2007·Immunologic Research·Ryan A Langlois, Kevin L Legge
Feb 25, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marta Rodríguez-GarcíaTeresa Gallart
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Marc BeyerJürgen Schwarze
Mar 24, 2004·Trends in Microbiology·Florence NiedergangJean-Claude Sirard
Oct 11, 2003·Pharmacology & Therapeutics·John W Upham, Philip A Stumbles
Aug 3, 2001·Vaccine·P MoingeonA Lindberg
Jul 19, 2000·Current Opinion in Immunology·V E Schijns
Aug 17, 1999·Current Opinion in Immunology·C Reis e SousaP Kaye
Jul 11, 2001·Microbes and Infection·K H Mills
Dec 22, 1999·Allergy·W J Fokkens
Feb 19, 2009·Immunology and Cell Biology·Shanjana AwasthiGary White
May 9, 2012·Nature Medicine·Stephen T Holgate
Sep 13, 2002·Immunology and Cell Biology·Lois L Cavanagh, Ulrich H Von Andrian
May 20, 2003·Respirology : Official Journal of the Asian Pacific Society of Respirology·John W Upham
Jun 6, 2009·The New England Journal of Medicine·Manuel G CosioAlvar Agusti
May 20, 1999·The Journal of Experimental Medicine·L LefrançoisL Puddington
Feb 17, 1999·The Journal of Experimental Medicine·C RobertT S Kupper
Nov 8, 2006·The Journal of Experimental Medicine·Deborah H StricklandPatrick G Holt
Jul 2, 2008·The Journal of Experimental Medicine·Jodi McGillKevin L Legge
May 16, 2012·The Journal of Experimental Medicine·Emily E ThorntonMatthew F Krummel
Aug 20, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Patrick G Holt
Mar 23, 2001·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·P G Holt, P A Stumbles
Dec 12, 2002·Current Opinion in Pulmonary Medicine·Bart N Lambrecht, Hamida Hammad
Apr 16, 2008·Journal of Gastroenterology and Hepatology·Anna B PulimoodKunnissery A Balasubramanian

❮ Previous
Next ❯