Dendritic cells continue to capture and present antigens after maturation in vivo.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Scott B Drutman, E Sergio Trombetta

Abstract

Dendritic cell (DC) maturation is critical for the regulation of T cell responses. The downregulation of endocytosis on maturation is considered a key adaptation that dissociates prior Ag capture by DCs from subsequent T cell engagement. To study the dynamics of Ag capture and presentation in situ, we studied the capacity for Ag uptake by DCs matured in their natural tissue environment. We found that after maturation in vivo, mouse DCs retained a robust capacity to capture soluble Ags. Furthermore, Ags internalized by mature DCs were efficiently presented on MHC class II and cross-presented on MHC class I. These results suggest that under inflammatory conditions, mature DCs may contribute to T cell stimulation without exclusively relying on prior exposure to Ags as immature DC precursors.

References

Jul 1, 1990·The Journal of Experimental Medicine·M CrowleyR M Steinman
Aug 1, 1995·The Journal of Experimental Medicine·R M Steinman, J Swanson
Aug 1, 1993·The Journal of Experimental Medicine·C Reis e SousaJ M Austyn
Jan 20, 1997·The Journal of Experimental Medicine·C WinzlerP Ricciardi-Castagnoli
Jun 8, 1999·Annual Review of Immunology·A Aderem, D M Underhill
Jan 13, 2000·Immunological Reviews·S Amigorena, C Bonnerot
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
May 24, 2001·Immunity·C Reis e Sousa
Feb 28, 2002·Annual Review of Immunology·Charles A Janeway, Ruslan Medzhitov
Feb 28, 2002·Annual Review of Immunology·Pierre GuermonprezSebastian Amigorena
Mar 1, 2003·Science·E Sergio TrombettaIra Mellman
Apr 19, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandip K DattaEyal Raz
Feb 10, 2004·European Journal of Immunology·Beatriz C Gil-TorregrosaSebastian Amigorena
Apr 7, 2004·Trends in Cell Biology·Marianne BoesHidde Ploegh
May 15, 2004·Immunity·Jacques BanchereauA Karolina Palucka
Aug 25, 2004·Science·Federica BenvenutiSebastian Amigorena
Jan 26, 2005·Trends in Immunology·Amy Y Chow, Ira Mellman
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria MontoyaPersephone Borrow
Mar 18, 2005·Annual Review of Immunology·E Sergio Trombetta, Ira Mellman
Apr 9, 2005·European Journal of Immunology·Eric MurailleGregoire Lauvau
Sep 27, 2005·Immunological Reviews·Peter CresswellPamela A Wearsch
Jan 21, 2006·Nature Immunology·Heather D Hickman-Miller, Jonathan W Yewdell
May 13, 2006·Nature Reviews. Immunology·Caetano Reis e Sousa
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sven BurgdorfChristian Kurts
Aug 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea J WolfJoel D Ernst

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Citations

Feb 22, 2013·Clinical and Vaccine Immunology : CVI·Sara E Herrera-RodríguezCiro Estrada-Chávez
May 13, 2011·American Journal of Respiratory and Critical Care Medicine·Leonie S van RijtBart N Lambrecht
Oct 8, 2013·PloS One·Claudia S WagnerPeter Cresswell
Oct 16, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Tzu-Yang WengMing-Derg Lai
Dec 21, 2014·World Journal of Surgical Oncology·Masanori KobayashiMasaki Nagaya
Feb 28, 2015·Nature Reviews. Immunology·Paul A Roche, Kazuyuki Furuta
Jun 10, 2014·Frontiers in Immunology·Lillian Cohn, Lélia Delamarre
Mar 1, 2018·Annual Review of Immunology·J Magarian Blander
Nov 1, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph CalmetteGéraldine Schlecht-Louf
Dec 7, 2017·Oncoimmunology·Stefano PieriniLorenzo Galluzzi
Jan 30, 2018·Frontiers in Immunology·Matthias P DomogallaKerstin Steinbrink
Jan 5, 2011·Immunological Reviews·Heather D HickmanJonathan W Yewdell
Jun 21, 2016·Immunological Reviews·Andrés AlloattiSebastian Amigorena
Jan 31, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyung-Jin ChoPaul A Roche
Dec 14, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia S Wagner, Peter Cresswell
Nov 7, 2012·Traffic·Adriana R MantegazzaMichael S Marks
Mar 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott B DrutmanE Sergio Trombetta
Jun 7, 2020·Molecular Neurodegeneration·Jatin MachhiHoward E Gendelman
Sep 10, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier Vega-RamosJose A Villadangos
Apr 17, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lorena M CoriaJuliana Cassataro
Nov 14, 2018·Immunogenetics·Mollie M Jurewicz, Lawrence J Stern
Mar 18, 2011·European Journal of Immunology·Jurjen TelI Jolanda M de Vries
Dec 15, 2020·Current Protocols in Immunology·Barzan A SadiqJ Magarian Blander
Apr 2, 2021·Nature Immunology·Gaëtan BarbetJ Magarian Blander
Jun 24, 2016·Microbiology Spectrum·Paul A Roche, Peter Cresswell
Aug 8, 2021·International Journal of Molecular Sciences·Emma Probst BrandumGertrud Malene Hjortø
May 28, 2019·Advanced Drug Delivery Reviews·Yoosoo YangIn-San Kim

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