Dendritic cells cross-talk with tumour antigen-specific CD8+ T cells, Vγ9γδT cells and Vα24NKT cells in patients with glioblastoma multiforme and in healthy donors

Clinical and Experimental Immunology
Yuuta EirakuMie Nieda

Abstract

The finding that dendritic cells (DCs) orchestrate innate and adaptive immune responses has stimulated research on harnessing DCs for developing more effective vaccines for DC therapy. The expression of cytomegalovirus (CMV) antigens in glioblastoma multiforme (GBM) presents a unique opportunity to target these viral proteins for tumour immunotherapy. Here, we demonstrate that Vγ9γδT cells, innate immune cells activated by zoledronate (Z) and Vα24 natural killer (Vα24NK) cells, innate/adaptive immune cells activated by α-galactosylceramide (G) can link innate and adaptive immunities through cross-talk with interferon (IFN) DCs from patients with glioblastoma multiforme (GBM) and healthy donors in a manner that can amplify the activation and proliferation of CMVpp65-specific CD8+ T cells. The IFN DCs derived from patients with GBM used in this study express lower levels of programmed cell death ligand (PD)-L1 and PD-L2 and higher levels of C-C receptor 7 (CCR7) than the most commonly used mature interleukin (IL)-4 DCs. The expression level of programmed cell death 1 (PD-1) on CD8+ T cells, including CMVpp65-specific CD8+ T cells, expanded by IFN DCs pulsed with the CMVpp65-peptide and Z plus G (IFN DCs/P+Z+G), was lower than tha...Continue Reading

References

Dec 1, 1990·Annals of Neurology·J P ImperatoN A Vick
Oct 23, 1998·The Journal of Experimental Medicine·F M SpadaS A Porcelli
Feb 28, 2002·Annual Review of Immunology·Beatriz M Carreno, Mary Collins
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohide YamazakiHideo Yagita
Sep 25, 2003·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael BoeckhJohn Zaia
Oct 14, 2003·Trends in Immunology·Beatriz M Carreno, Mary Collins
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Apr 2, 2005·Nature Reviews. Immunology·Jacques Banchereau, A Karolina Palucka
Jun 4, 2005·Science·Marlène BrandesBernhard Moser
Jul 28, 2006·Immunology and Cell Biology·Shigemi SasawatariKazuhiro Kakimi
Dec 30, 2006·Cancer Immunology, Immunotherapy : CII·Christian Blank, Andreas Mackensen
Jul 27, 2007·Journal of Virology·Min Hua Luo, Elizabeth A Fortunato
Aug 2, 2008·The New England Journal of Medicine·Robert M PrinsLinda M Liau
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ingrid E DumitriuChristopher D Gregory
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jun 15, 2011·Trends in Biotechnology·Tristen S ParkRichard A Morgan
Jul 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara CastellaMassimo Massaia
Oct 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrick A OttCaroline Robert
Mar 25, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Smita K NairDuane A Mitchell
Mar 13, 2015·Nature·Rachel Lubong Sabado, Nina Bhardwaj
Apr 24, 2015·Cancer Immunology, Immunotherapy : CII·Masato MutoKen-Ichiro Seino
Sep 2, 2015·The Journal of Clinical Investigation·Lieping Chen, Xue Han
Aug 17, 2016·Nature Reviews. Immunology·Daniel E SpeiserGrégory Verdeil
Nov 29, 2016·Nature Reviews. Immunology·Tim WorbsReinhold Förster
Dec 21, 2016·Cell Research·Atsushi Tanaka, Shimon Sakaguchi
Aug 9, 2017·Current Treatment Options in Oncology·Russell MaxwellMichael Lim

❮ Previous
Next ❯

Citations

Nov 17, 2020·Frontiers in Immunology·Xianhui KangWujun Geng

❮ Previous
Next ❯

Methods Mentioned

BETA
density gradient centrifugation

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis