PMID: 9531351Apr 8, 1998Paper

Dendritic cells cultured from mononuclear cells and CD34 cells in myeloma do not harbour human herpesvirus 8

British Journal of Haematology
G M CullB J Thomson

Abstract

Dendritic cells (DC) are antigen-presenting cells with the potential to be a powerful adjuvant in the immunotherapy of haematological malignancy, including myeloma. Recently, human herpesvirus 8 (HHV-8) infection of dendritic cells in the long-term bone marrow stromal cultures of patients with myeloma has been reported. This finding is of great potential importance regarding oncogenesis in myeloma in addition to having significant implications for the use of DC in the immunotherapy of this disease. Therefore DC generated from mobilized blood mononuclear cells (MO-DC) and purified CD34+ cells (CD34-DC) of myeloma patients were examined for the presence of HHV-8 using a sensitive PCR technique. HHV-8 was not demonstrated in MO-DC or CD34-DC and we conclude that these cells remain a suitable vehicle for investigation in the immunotherapy of myeloma.

References

May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Mar 25, 1995·Lancet·Y Q HuangA E Friedman-Kien
Jul 1, 1994·The Journal of Experimental Medicine·N RomaniG Schuler
Jun 1, 1997·Molecular Medicine Today·W C van SchootenV Palathumpat
Oct 31, 1997·Lancet·A G MarcelinV Calvez
Oct 31, 1997·Lancet·J MacKenzieR F Jarrett

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Citations

Jun 26, 1999·Medical Oncology·G GaidanoP Biberfeld
Dec 13, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J C LeaoC Scully
Jul 29, 2000·Australian and New Zealand Journal of Medicine·D E Joshua, J Gibson
Apr 7, 1999·British Journal of Haematology·T PapoP Cacoub
Dec 2, 2000·Seminars in Cancer Biology·J R BerensonR A Vescio
Sep 16, 2014·Frontiers in Microbiology·Diana M CampbellCharles R Rinaldo
Sep 24, 2002·Revista do Hospital das Clínicas·Jair Carneiro LeãoCrispian Scully
Jan 8, 2000·Hematology/oncology Clinics of North America·N N Sjak-ShieJ R Berenson
Jul 2, 1999·British Journal of Cancer·M DeichmannH Näher
Dec 11, 1999·Proceedings of the Association of American Physicians·F NeipelB Fleckenstein

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