Dendritic cells derived from BCG-infected precursors induce Th2-like immune response

Journal of Leukocyte Biology
Angelo MartinoSilvia Vendetti

Abstract

Human monocytes can differentiate into dendritic cells (DCs) according to the nature of environmental signals. We tested here whether the infection with the live tuberculosis vaccine bacillus Calmette-Guerin (BCG), which is known to be limited in preventing pulmonary tuberculosis, modulates monocyte and DC differentiation. We found that monocytes infected with BCG differentiate into CD1a- DCs (BCG-DCs) in the presence of granulocyte macrophage-colony stimulating factor and interleukin (IL)-4 and acquired a mature phenotype in the absence of maturation stimuli. In addition, BCG-DCs produced proinflammatory cytokines (tumor necrosis factor alpha, IL-1beta, IL-6) and IL-10 but not IL-12. BCG-DCs were able to stimulate allogeneic T lymphocytes to a similar degree as DCs generated in the absence of infection. However, BCG-DCs induced IL-4 production when cocultured with human cord-blood mononuclear cells. The induction of IL-4 production by DCs generated by BCG-infected monocytes could explain the failure of the BCG vaccine to prevent pulmonary tuberculosis.

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Citations

Apr 7, 2006·Journal of Clinical Immunology·Angelo MartinoPatrizia Morena Baldini
Oct 24, 2007·Journal of Biosciences·Angelo Martino
Apr 1, 2008·Journal of Biosciences·Angelo Martino
Aug 2, 2005·Nature Reviews. Immunology·Graham A W RookAlimuddin Zumla
Nov 29, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Alessandra SacchiSilvia Vendetti
Nov 15, 2006·Infection and Immunity·Peter MitchellGiovanna Lombardi
Dec 17, 2009·Immunology Letters·Heidi A Schreiber, Matyas Sandor
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Sep 12, 2014·Molecular Cancer·Sahana HollaKithiganahalli Narayanaswamy Balaji
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Aug 10, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Alagar Manickam, Muthukumaran Sivanandham
Mar 22, 2014·Journal of Leukocyte Biology·Ester SciaraffiaSilvia Vendetti
Nov 11, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Preetam BasakDevi Dayal
May 7, 2021·Immunological Reviews·Asma AhmedAnnapurna Vyakarnam

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