PMID: 9557664Apr 29, 1998Paper

Dendritic cells efficiently induce protective antiviral immunity

Journal of Virology
Burkhard LudewigR M Zinkernagel

Abstract

Cytotoxic T lymphocytes (CTL) are essential for effective immunity to various viral infections. Because of the high speed of viral replication, control of viral infections imposes demanding functional and qualitative requirements on protective T-cell responses. Dendritic cells (DC) have been shown to efficiently acquire, transport, and present antigens to naive CTL in vitro and in vivo. In this study, we assessed the potential of DC, either pulsed with the lymphocytic choriomeningitis virus (LCMV)-specific peptide GP33-41 or constitutively expressing the respective epitope, to induce LCMV-specific antiviral immunity in vivo. Comparing different application routes, we found that only 100 to 1,000 DC had to reach the spleen to achieve protective levels of CTL activation. The DC-induced antiviral immune response developed rapidly and was long lasting. Already at day 2 after a single intravenous immunization with high doses of DC (1 x 10(5) to 5 x 10(5)), mice were fully protected against LCMV challenge infection, and direct ex vivo cytotoxicity was detectable at day 4 after DC immunization. At day 60, mice were still protected against LCMV challenge infection. Importantly, priming with DC also conferred protection against infectio...Continue Reading

References

Aug 1, 1976·Transplantation·K J LaffertyD W Talmage
May 1, 1990·The Journal of Experimental Medicine·P AicheleM Schulz
Jan 11, 1991·Science·S OehenR M Zinkernagel
Jan 1, 1991·Annual Review of Immunology·R M Steinman
Feb 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M SchulzH Hengartner
Apr 1, 1989·The Journal of Experimental Medicine·S E MacatoniaB A Askonas
Jul 1, 1967·Transplantation·C F Barker, R E Billingham
Jul 1, 1995·The Journal of Experimental Medicine·P AicheleH Pircher
Apr 1, 1994·Current Opinion in Immunology·M F Bachmann, T M Kündig
Mar 1, 1994·European Journal of Immunology·V FlamandM Moser
Aug 1, 1996·The Journal of Experimental Medicine·D BoczkowskiE Gilboa
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·T M KündigR M Zinkernagel
Oct 1, 1996·Nature Medicine·C CondonL D Falo
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·M F BachmannR M Zinkernagel

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Citations

Oct 23, 1998·The Journal of Experimental Medicine·B LudewigR M Zinkernagel
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Detlef StoberJörg Reimann
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christof BerberichHeidrun Moll
Oct 1, 2005·Leukemia & Lymphoma·D Nachbaur, B Kircher
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tae-Bong KangDavid Wallach
Oct 24, 2008·Journal of Virology·Martin S ZinkernagelBurkhard Ludewig
Jun 14, 2013·PloS One·Aaruni KhanolkarJohn T Harty
May 21, 2019·European Journal of Immunology·Julia M ColstonPaul Klenerman
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·A F OchsenbeinR M Zinkernagel
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B LudewigR M Zinkernagel
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jan C DuddaStefan Martin
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·B LudewigH Hengartner
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D VoehringerH Pircher
Feb 1, 2003·The Journal of General Virology·Françoise LenfantAnatolij Horuzsko
Sep 19, 2003·The Journal of General Virology·Gisela SobollD Paul Lunn
Aug 2, 2007·Expert Opinion on Biological Therapy·Massimo Trucco, Nick Giannoukakis
Sep 8, 2012·Blood·Lucas OnderBurkhard Ludewig
Feb 25, 2015·Immunology and Cell Biology·Andrew J HightonRoslyn A Kemp
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela BacciLuigina Romani
Apr 13, 2000·Immunology and Cell Biology·L H StockwinG E Blair
Jul 19, 2002·ANZ Journal of Surgery·Veronica YaoJohn C Hall
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippe KrebsBurkhard Ludewig
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eirini I RigopoulouNikolai V Naoumov
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tobias JuntBurkhard Ludewig
Jul 3, 2007·Molecular Plant-microbe Interactions : MPMI·Il-Pyung AhnSeok-Cheol Suh
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ken CoppietersMatthias G von Herrath
Dec 23, 2015·Viruses·Youra KimPatrick W K Lee

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