PMID: 9537588Apr 16, 1998Paper

Dendritic cells fused with mastocytoma cells elicit therapeutic antitumor immunity

International Journal of Cancer. Journal International Du Cancer
L LespagnardM Moser

Abstract

Characterization of the spontaneous immune response that frequently occurs in tumor-bearing animals, as well as immunization using dendritic cells pulsed with tumor antigens, suggests that a limiting factor of the tumor-specific immune response may be a defect in the co-stimulatory signal that is required for optimal activation of T cells. In this work, we describe a new approach to improve the antigen-presenting capacity of tumor cells, which does not require a source of purified tumor-associated antigen. We fused P815 mastocytoma cells with bone marrow-derived dendritic cells. We obtained one hybrid that displayed the phenotypic and functional properties of dendritic cells and expressed mRNA coding for the tumor-associated antigen P815 A/B. Injections of irradiated hybrid cells prevented the growth of preimplanted mastocytoma and induced long-lasting tumor resistance.

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Citations

Feb 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·J GongD Kufe
Feb 11, 2010·Journal of Immunotherapy·Jacalyn RosenblattDavid Avigan
May 5, 2011·Journal of Biomedicine & Biotechnology·Shigeo KoidoHisao Tajiri
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Feb 26, 2010·Clinical & Developmental Immunology·Shigeo KoidoHisao Tajiri
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J GongD Kufe
Apr 10, 2010·Journal of Biomedicine & Biotechnology·Shigeo KoidoHisao Tajiri
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