Dendritic Cells in Anticancer Vaccination: Rationale for Ex Vivo Loading or In Vivo Targeting

Cancers
Alexey V BaldinAndrey A Zamyatnin

Abstract

Dendritic cells (DCs) have shown great potential as a component or target in the landscape of cancer immunotherapy. Different in vivo and ex vivo strategies of DC vaccine generation with different outcomes have been proposed. Numerous clinical trials have demonstrated their efficacy and safety in cancer patients. However, there is no consensus regarding which DC-based vaccine generation method is preferable. A problem of result comparison between trials in which different DC-loading or -targeting approaches have been applied remains. The employment of different DC generation and maturation methods, antigens and administration routes from trial to trial also limits the objective comparison of DC vaccines. In the present review, we discuss different methods of DC vaccine generation. We conclude that standardized trial designs, treatment settings and outcome assessment criteria will help to determine which DC vaccine generation approach should be applied in certain cancer cases. This will result in a reduction in alternatives in the selection of preferable DC-based vaccine tactics in patient. Moreover, it has become clear that the application of a DC vaccine alone is not sufficient and combination immunotherapy with recent advance...Continue Reading

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Citations

Aug 28, 2020·Expert Opinion on Biological Therapy·Elnaz FaghfuriBehzad Baradaran
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Jun 3, 2021·Cancers·Kazuhiko MatsuoTakashi Nakayama

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Methods Mentioned

BETA
chemical modification
transgenic
genetic modifications
leukapheresis
genetic modification
transfection

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Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

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