Dendritic cells in islets of Langerhans constitutively present beta cell-derived peptides bound to their class II MHC molecules.

Proceedings of the National Academy of Sciences of the United States of America
Boris CalderonEmil R Unanue

Abstract

Islets of Langerhans from normal mice contained dendritic cells (DCs) in the range of 8-10 per islet. DCs were found in several mouse strains, including those from lymphocyte-deficient mice. DCs were absent in islets from colony stimulating factor-1 deficient mice and this absence correlated with small size islets. Most DCs were found next to blood vessels and resided in islets for several days. Some DCs contained insulin-like granules, and most expressed peptide-MHC complexes derived from beta cell proteins. Islet DCs were highly effective in presenting beta cell antigens to CD4 T cells ex vivo. Presentation of beta cell-derived peptide-MHC complexes by DCs neither depended on islet inflammation nor correlated with the extent of spontaneous beta cell death. Periislet stroma DCs did not contain beta cell peptide-MHC complexes; however, 50% of DCs in pancreatic node were positive. Hence, presentation of high levels of beta cell antigens normally takes place by islet DCs, a finding that has to be placed in the perspective of autoimmune diabetes.

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Citations

Sep 8, 2012·Immunologic Research·Jordan JacobelliRachel S Friedman
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Boris CalderonEmil R Unanue
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Boris CalderonEmil R Unanue
Nov 9, 2011·The Journal of Experimental Medicine·James F MohanEmil R Unanue
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Mar 25, 2015·Molecular Endocrinology·Sarah A TerseyRaghavendra G Mirmira

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