Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines

Frontiers in Immunology
Laura GornatiFrancesca Granucci

Abstract

Vaccines represent the discovery of utmost importance for global health, due to both prophylactic action to prevent infections and therapeutic intervention in neoplastic diseases. Despite this, current vaccination strategies need to be refined to successfully generate robust protective antigen-specific memory immune responses. To address this issue, one possibility is to exploit the high efficiency of dendritic cells (DCs) as antigen-presenting cells for T cell priming. DCs functional plasticity allows shaping the outcome of immune responses to achieve the required type of immunity. Therefore, the choice of adjuvants to guide and sustain DCs maturation, the design of multifaceted vehicles, and the choice of surface molecules to specifically target DCs represent the key issues currently explored in both preclinical and clinical settings. Here, we review advances in DCs-based vaccination approaches, which exploit direct in vivo DCs targeting and activation options. We also discuss the recent findings for efficient antitumor DCs-based vaccinations and combination strategies to reduce the immune tolerance promoted by the tumor microenvironment.

References

Feb 1, 1974·The Journal of Experimental Medicine·R M Steinman, Z A Cohn
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Aug 30, 2001·Nature Immunology·F GranucciP Ricciardi-Castagnoli
Sep 19, 2001·The Journal of Experimental Medicine·D HawigerM C Nussenzweig
Oct 3, 2002·The Journal of Cell Biology·Thalia BeckerFelix Wieland
Mar 5, 2003·Annual Review of Immunology·Ralph M SteinmanMichel C Nussenzweig
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·John Y KaoJian-Jun Chen
Mar 17, 2004·The Journal of Experimental Medicine·Laura C BonifazRalph M Steinman
Jul 6, 2004·Immunological Reviews·William R HeathJose A Villadangos
Aug 4, 2004·The Journal of Experimental Medicine·Francesca GranucciPaola Ricciardi-Castagnoli
Nov 25, 2004·Advanced Drug Delivery Reviews·Ying Waeckerle-Men, Marcus Groettrup
Jul 9, 2005·Biochemical and Biophysical Research Communications·Sreenivas LaxmananDebabrata Mukhopadhyay
Mar 1, 2006·The Journal of Experimental Medicine·Silvia B BoscardinMichel C Nussenzweig
Mar 1, 2006·The Journal of Experimental Medicine·Christine TrumpfhellerRalph M Steinman
Apr 4, 2006·International Immunology·Masato KatoDerek N J Hart
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giandomenica IezziManfred Kopf
Nov 7, 2006·Cancer Immunology, Immunotherapy : CII·Kousaku MimuraHideki Fujii
Jan 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Leonia BozzaccoRalph M Steinman
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helen S GoodridgeDavid M Underhill
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karoline W SchjetneBjarne Bogen
Jul 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Rajesh RavindranStephen J McSorley
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrizia StoitznerFranca Ronchese
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liangchun WangKristin A Hogquist
Apr 15, 2008·The Journal of Biological Chemistry·Cristal HuysamenGordon D Brown
May 24, 2008·The Journal of Clinical Investigation·David SanchoCaetano Reis e Sousa
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hanfen LiFabio Re
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mirjam KoolJürg Tschopp
Nov 13, 2008·Cellular and Molecular Life Sciences : CMLS·K MutyambiziR L Edelson

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Citations

Sep 29, 2019·Cancer Immunology, Immunotherapy : CII·Marlene Fyrstenberg LaursenRalf Agger
Jul 13, 2019·Frontiers in Immunology·Mariano MalamudMaría de Los Ángeles Serradell
Dec 8, 2020·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham RobertsJ A Woodfolk
Sep 23, 2021·Expert Review of Vaccines·Henderson ZhuAndrew J Pollard

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Methods Mentioned

BETA
nuclear translocation
transfection

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NCT03358719
NCT01834248
NCT02166905
NCT01522820
NCT03329950
NCT02706353
NCT03214250
NCT03389802
NCT03418480
NCT03123783

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