Dendritic cells interacting mainly with B cells in the lymphoepithelial symbiosis of the human palatine tonsil

Virchows Archiv : an International Journal of Pathology
Kiyoshi TakahashiKatsuya Miyatani

Abstract

The lymphoepithelial symbiosis (LES) of the human palatine tonsil is composed of spindle- or star-shaped epithelial cells forming a loose meshwork, containing numerous lymphocytes and dendritic cells (DCs). In the present study, we immunohistochemically characterized DCs in the LES (LES-DCs). LES-DCs were phenotypically immature DCs that were S100beta+, fascin-, HLA-DR+, CD1a-, CD80-, CD83-, CD86-, and CD123-. The most characteristic feature of LES-DCs was that they contacted many B cells, which were mostly IgM+ IgD+ resting naive B cells. Langerhans cells (LCs) located in the nonsymbiotic squamous epithelium were immature DCs that were S100beta+, fascin-, and CD1a+ and did not contact lymphocytes. In contrast to LES-DCs, interdigitating dendritic cells (IDCs) in the T zone were mature DCs that were HLA-DR+, CD1a-, fascin+, CD80+, CD83+, and CD86+ and contacted numerous CD4+ T cells. Two subsets of IDC, S100beta+ fascin+ IDC (IDC-1) and S100beta- fascin+ IDC (IDC-2), were identified, and the majority of IDCs are IDC-2. In contrast to IDCs, which were distributed in the T-cell area in groups, LES-DCs were distributed along the crypt as if forming a barrier. These findings suggest that LES-DCs are a novel type of DC playing an im...Continue Reading

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Citations

Mar 24, 2007·Annual Review of Immunology·Akiko Iwasaki
May 29, 2009·Journal of Clinical and Experimental Hematopathology : JCEH·Yuriko NishikawaKiyoshi Takahashi
Dec 17, 2009·Otolaryngologia polska. The Polish otolaryngology·Beata Zelazowska-RutkowskaMałgorzata Mrugacz
Dec 12, 2018·Advanced Healthcare Materials·Rachel L Creighton, Kim A Woodrow
Dec 6, 2020·Scientific Reports·Kevin MellertPeter Möller
May 11, 2021·Neuroscience and Biobehavioral Reviews·Fabrizio MichettiFrancesco Ria

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