PMID: 9419451Jan 7, 1998Paper

Dendritic cells, interleukin 12, and CD4+ lymphocytes in the initiation of class I-restricted reactivity to a tumor/self peptide

Critical Reviews in Immunology
U GrohmannP Puccetti

Abstract

Cell-mediated immunity involving CD8+ lymphocytes is effective in mediating rejection of murine mastocytoma cells bearing P815AB, a tumor-associated and self antigen showing similarity to tumor-specific shared antigens in humans. Although this antigen may act as an efficient target for class I-restricted responses in immunized mice, neither P815AB expressed on tumor cells nor a related synthetic nonapeptide will activate unprimed CD8+ cells for in vivo reactivity, measured by skin test assay. We review evidence showing that the failure of P815AB to initiate CD8+ cell reactivity may be due to defective recruitment of accessory and Th1-like cells to the afferent phase of the response initiated by transfer of mice with dendritic cells pulsed in vitro with the P815AB peptide. Although the copresence of a T helper peptide in dendritic cell priming in vitro with P815AB may compensate for the poor generation of accessory and Th1 cells in the adoptively transferred mice, recombinant IL-12 can replace the helper peptide in both effects. Effective priming to P815AB in vivo is achieved by either exposing dendritic cells to IL-12 prior to P815AB priming or administering the recombinant cytokine in vivo. Different approaches suggest that IL...Continue Reading

Citations

Oct 26, 1999·Critical Reviews in Oncology/hematology·J D KerrebijnH A Drexhage
Jun 19, 2002·American Journal of Respiratory and Critical Care Medicine·Tomoyoshi TsuchiyaHirotoshi Nakamura
Jun 7, 2000·The Journal of Clinical Investigation·H N LodeR A Reisfeld
Dec 25, 2003·Leukemia & Lymphoma·E R KaminskiA G Prentice
Nov 7, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S S PendseM H Frank
Apr 1, 2004·International Journal of Cancer. Journal International Du Cancer·Iñigo TirapuIgnacio Melero
Dec 18, 2001·British Journal of Cancer·L S KiersteadW J Storkus
Feb 27, 2004·Immunology and Cell Biology·Georg BehrensWilliam R Heath
Oct 16, 2001·Drugs & Aging·S Matzku, M Zöller
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P TerheydenJ C Becker
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U GrohmannP Puccetti
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·U GrohmannP Puccetti
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·U GrohmannP Puccetti
Oct 3, 1999·International Journal of Cancer. Journal International Du Cancer·B CochloviusM Zöller
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G PirtskhalaishviliM R Shurin
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B CochloviusM Zöller
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Zöller, O Christ
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Po-Hui ChiangShiguang Qian
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria Laura BelladonnaPaolo Puccetti
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y WanK Dayball
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·F FallarinoP Puccetti
Feb 29, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·H SwiniarskiM O'Toole

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

International Journal of Cancer. Journal International Du Cancer
D C Flyer, B Sucheski
European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
A GüngörB Sözeri
© 2021 Meta ULC. All rights reserved