Dendritic cells loaded with tumor derived exosomes for cancer immunotherapy

Hongyu LiuTianyi Liu


Exosomes are vesicles that can be secreted by many types of cell and released into the extracellular space. Studies have found that tumor derived exosomes (TEXs) can promote tumor growth and metastasis, as well as inhibit immune response through transferring their genetic information to the recipient cells. Given their functions in tumor progression, TEXs are considered as promising biomarkers for early detection of human malignancy. Dendritic cells (DCs), a type of antigen presenting cells, can induce tumor-specific T cell immune responses in carcinogenesis. Growing evidences have demonstrated that the matured DCs induced by TEXs exhibit enhanced anti-tumor effects that may be applied for cancer immunotherapy. Thus in this review, according to the previous studies, we summarized the effects of DCs loaded with TEXs in cancer immunotherapy.


Mar 1, 1996·The Journal of Experimental Medicine·G RaposoH J Geuze
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C ThéryS Amigorena
May 22, 2002·The Journal of Experimental Medicine·Giovanna AndreolaStefano Fais
Jul 31, 2002·Lancet·Fabrice AndreLaurence Zitvogel
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fabrice AndréLaurence Zitvogel
Feb 23, 2005·Journal of Translational Medicine·Michael A MorseH Kim Lyerly
Mar 15, 2005·American Journal of Respiratory and Critical Care Medicine·Joost P J J HegmansBart N Lambrecht
Aug 6, 2005·Blood Cells, Molecules & Diseases·Ashraf J AbusamraWei-Ping Min
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cunren LiuHuang-Ge Zhang
Aug 1, 2006·Journal of Biochemistry·Guillaume van NielGraça Raposo
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shaohua YuHuang-Ge Zhang
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aled ClaytonZsuzsanna Tabi
Jul 1, 2008·Gynecologic Oncology·Douglas D Taylor, Cicek Gercel-Taylor
Oct 15, 2008·PloS One·Venkateswara Rao SimhadriElke Pogge von Strandmann
Nov 5, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daniel H PalmerDavid H Adams
Dec 20, 2008·The Journal of International Medical Research·F GuoL H Zhao
Feb 5, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mehmet KesimerJohn K Sheehan
Jun 6, 2009·Nature Reviews. Immunology·Clotilde ThéryElodie Segura
Aug 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eva U WieckowskiTheresa L Whiteside
Mar 30, 2010·The American Journal of Pathology·Yuelong LiuHuang-Ge Zhang
Dec 23, 2011·Clinical & Developmental Immunology·Chenjie Yang, Paul D Robbins
Aug 18, 2012·Immunology Letters·Annamaria MartonKrisztina Buzas
Nov 14, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martin K HunnIan F Hermans
Mar 29, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Zhi-Ming LiuXian-Hou Yuan
May 28, 2013·Biochemical and Biophysical Research Communications·Ye YaoSiguo Hao
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Nov 14, 2013·Journal of Extracellular Vesicles·Niken M MahaweniJoost P J J Hegmans

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