Dendritic cells, pro-inflammatory responses, and antigen presentation in a rodent malaria infection

Immunological Reviews
Jean LanghorneAnne-Marit Sponaas

Abstract

An infection of mice with Plasmodium chabaudi is characterized by a rapid and marked inflammatory response with a rapid but regulated production of interleukin-12 (IL-12), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma). Recent studies have shown that dendritic cells (DCs) are activated in vivo in the spleen, are able to process and present malaria antigens during infection, and may provide a source of cytokines that contribute to polarization of the CD4 T-cell response. P. chabaudi-infected erythrocytes are phagocytosed by DCs, and peptides of malaria proteins are presented on major histocompatibility complex (MHC) class II. The complex disulfide-bonded structure of some malaria proteins can impede their processing in DCs, which may affect the magnitude of the CD4 T-cell response and influence T-helper 1 (Th1) or Th2 polarization. DCs exhibit a wide range of responses to parasite-infected erythrocytes depending on their source, their maturational state, and the Plasmodium species or strain. P. chabaudi-infected erythrocytes stimulate an increase in the expression of costimulatory molecules and MHC class II on mouse bone marrow-derived DCs, and they are able to induce the production of pro-inflammatory...Continue Reading

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Citations

Feb 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Bernardo S FranklinRicardo T Gazzinelli
Jul 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tiffany SunRichard Bucala
Jun 7, 2006·The Journal of Experimental Medicine·Anne-Marit SponaasJean Langhorne
Feb 22, 2007·The Journal of Experimental Medicine·Gundula Min-OoPhilippe Gros
Dec 21, 2011·The Journal of Experimental Medicine·Jannik FonagerBlandine M D Franke-Fayard
Oct 1, 2008·Infection and Immunity·Charles C KimJoseph L DeRisi
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