Dendritic cells strongly boost the antitumor activity of adoptively transferred T cells in vivo

Cancer Research
Yanyan LouPatrick Hwu

Abstract

Dendritic cells (DCs) have been well characterized for their ability to initiate cell-mediated immune responses by stimulating naive T cells. However, the use of DCs to stimulate antigen-activated T cells in vivo has not been investigated. In this study, we determined whether DC vaccination could improve the efficacy of activated, adoptively transferred T cells to induce an enhanced antitumor immune response. Mice bearing B16 melanoma tumors expressing the gp100 tumor antigen were treated with cultured, activated T cells transgenic for a T-cell receptor specifically recognizing gp100, with or without concurrent peptide-pulsed DC vaccination. In this model, antigen-specific DC vaccination induced cytokine production, enhanced proliferation, and increased tumor infiltration of adoptively transferred T cells. Furthermore, the combination of DC vaccination and adoptive T-cell transfer led to a more robust antitumor response than the use of each treatment individually. Collectively, these findings illuminate a new potential application for DCs in the in vivo stimulation of adoptively transferred T cells and may be a useful approach for the immunotherapy of cancer.

References

Feb 1, 1989·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherS A Rosenberg
Apr 15, 1974·International Journal of Cancer. Journal International Du Cancer·J WybranH H Fudenberg
Aug 3, 1994·Journal of the National Cancer Institute·S A RosenbergD E White
May 25, 1997·Cellular Immunology·L PengJ C Krauss
Nov 15, 1997·Journal of the National Cancer Institute·K R IrvineN P Restifo
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·K ShimizuJ J Mulé
Dec 22, 1999·European Journal of Immunology·S Rigby, M O Dailey
Mar 23, 2000·The Journal of Clinical Investigation·M V DhodapkarN Bhardwaj
Apr 26, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J S SerodyJ A Frelinger
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B Schuler-ThurnerG Schuler
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N Dalyot-HermanT R Malek
Nov 10, 2001·Annual Review of Genomics and Human Genetics·A Pfeifer, I M Verma
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·M H AndersenE Kämpgen
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naotaka Shibagaki, Mark C Udey
Mar 28, 2002·Cellular and Molecular Life Sciences : CMLS·A Pérez-Díez, F M Marincola
Sep 11, 2002·European Journal of Immunology·Reinout StoopKatalin Mikecz
Oct 31, 2002·Nature Immunology·Jonathan W Yewdell, Ann B Hill
Mar 14, 2003·Current Opinion in Immunology·Pierre G Coulie, Pierre van der Bruggen
Mar 14, 2003·Current Opinion in Immunology·Gerold SchulerRalph M Steinman
Aug 20, 2003·The Journal of Experimental Medicine·Willem W OverwijkNicholas P Restifo
Sep 3, 2003·Nature Reviews. Cancer·Mark E Dudley, Steven A Rosenberg
Dec 31, 2003·Nature Immunology·Vincenzo CerundoloMariolina Salio
Feb 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher A KlebanoffNicholas P Restifo

❮ Previous
Next ❯

Citations

Dec 4, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Whay-Kuang ChiaHan-Chong Toh
Nov 19, 2009·Cancer Immunology, Immunotherapy : CII·Mohamed Labib Salem, David J Cole
Feb 18, 2011·Cancer Immunology, Immunotherapy : CII·Sally M AmosMichael H Kershaw
Jun 29, 2010·Pigment Cell & Melanoma Research·Noriaki NakaiNorito Katoh
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chrystal M PaulosNicholas P Restifo
Jul 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thomas SchwaabMarc S Ernstoff
Oct 5, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Weiyi PengPatrick Hwu
Jul 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher A KlebanoffNicholas P Restifo
Feb 3, 2007·The Journal of Clinical Investigation·Claudio Anasetti, James J Mulé
May 4, 2007·The Journal of Clinical Investigation·Nina Bhardwaj
Jun 5, 2008·The Journal of Clinical Investigation·Laurence ZitvogelGuido Kroemer
Apr 30, 2005·Journal of Translational Medicine·Cassian Yee
Apr 6, 2011·Immunotherapy·John CopierAngus Dalgleish
Aug 27, 2011·Therapy·Thomas Schwaab, Marc S Ernstoff
Dec 12, 2007·International Journal of Biological Sciences·Qiao LiAlfred E Chang
Jun 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Christopher A KlebanoffNicholas P Restifo
Jan 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yong LuQing Yi
Aug 27, 2005·Expert Opinion on Biological Therapy·Gavin M BendleHans J Stauss
Mar 21, 2008·Vaccine·Francisca A NeethlingJon A Weidanz
Apr 24, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Jianhua HuangQiao Li
Jan 5, 2011·Immunological Reviews·Christopher A KlebanoffNicholas P Restifo
Dec 24, 2005·Pathology·Kristen J RadfordDerek N J Hart
Feb 12, 2008·Critical Reviews in Oncology/hematology·W J LesterhuisC J A Punt
Jun 18, 2015·Frontiers in Immunology·Jashodeep DattaBrian J Czerniecki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.