Abstract
Recent evidence suggested that angiogenesis played a pivotal role in the development of hepatocellular carcinoma cells (HCC), thus the therapy strategy targeting antiangiogenesis has been regarded as promising method for HCC therapy. Tumor endothelial marker 8 (TEM8) is a recently described protein that is preferentially expressed within tumor endothelium. However, the antiangiogenesis therapy of HCC based on TEM8 has not been reported. In this study, the recombinant adenovirus encoding TEM8 was constructed, and the DCs were transduced with the Ad-TEM8. In addition, the modified DCs were transferred into the BALB/c mice to determine whether DCs transduced with TEM8 could elicit a potent antitumor immunogenic response in vivo. The results demonstrated that DCs transduced with Ad-TEM8 induced specific CTLs effectively, which could secrete IFN-γ and lyse HCC. Furthermore, the modified DCs could effectively protect BALB/c mice from lethal challenges against HCC, reduce tumor growth and increase the mice life span by decreasing tumor vasculature density. These data suggest that the Ad-TEM8 modified DCs may induce antitumor immunity by disrupting tumor vasculature and may thus be used as an efficient therapy strategy to influence tum...Continue Reading
References
Jan 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R S Kerbel
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·J JouanneauJ P Thiery
Aug 19, 2000·Science·B St CroixK W Kinzler
Apr 21, 2001·Gene Therapy·S S DieboldM Zenke
Nov 9, 2001·Nature·K A BradleyJ A Young
Nov 10, 2001·Cytogenetics and Cell Genetics·S LoeperS Urbschat
Oct 3, 2002·Nature Reviews. Cancer·Robert Kerbel, Judah Folkman
Nov 19, 2003·Biochemical and Biophysical Research Communications·Malika BenouchanBruno M Colombo
Dec 20, 2003·Current Opinion in Oncology·Akash Nanda, Brad St Croix
Apr 6, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Gidon AlmogyAhmed Eid
Jul 16, 2004·Oncology Reports·Ray Chun-Fai Chan, Yong Xie
Mar 22, 2005·Experimental Cell Research·Kylie A HotchkissBruce I Terman
Jun 17, 2005·Cancer Research·Jakob DupontMichel Sadelain
Nov 30, 2005·Journal of Pharmaceutical Sciences·Haiyang HuXiuli Zhao
May 19, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Olivier AdotéviPierre Langlade-Demoyen
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eishiro MizukoshiShuichi Kaneko
May 9, 2007·Gastroenterology·Julia MallegolMartine Heyman
Dec 22, 2007·Oncology·Roberta W C Pang, Ronnie T P Poon
Mar 28, 2008·Immunological Reviews·Rong XiangRalph A Reisfeld
Apr 1, 2008·Surgical Oncology Clinics of North America·Travis KidnerYuman Fong
Jan 28, 2009·BMC Medical Genomics·Hui DongWeirong Jin
May 15, 2009·The American Journal of Surgical Pathology·Hiroshi YamaguchiToru Furukawa
May 26, 2009·Cancer Letters·Tetsuhiro ChibaAtsushi Iwama
Jun 6, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Terence Kin Wah LeeIrene Oi Lin Ng
Jun 23, 2009·Expert Opinion on Drug Delivery·Bei ChenKaichun Wu
Jul 18, 2009·Journal of Immunotherapy·Zhihua RuanYuzhang Wu
Citations
Feb 3, 2015·Biochimica Et Biophysica Acta·Madelon Q WentinkArjan W Griffioen
Feb 22, 2012·Cancer Cell·Amit ChaudharyBrad St Croix
Jan 20, 2016·PloS One·N J AndersenN S Duesbery
Mar 22, 2016·Scientific Reports·Chuangjie CaoLiantang Wang
Mar 1, 2013·Hepatology International·Iván Lyra-GonzálezJuan Armendáriz-Borunda
Oct 30, 2015·Journal of Translational Medicine·Samuel C WagnerSantosh Kesari
Oct 3, 2017·Biological & Pharmaceutical Bulletin·Tetsuya NomuraNaoki Utoguchi
Oct 18, 2019·PloS One·Kristina PetrovicSteven P Lee
Jul 2, 2014·Molecular Pharmaceutics·Frank KuoElaine M Jagoda