Dendritic cells transduced with TEM8 recombinant adenovirus prevents hepatocellular carcinoma angiogenesis and inhibits cells growth

Vaccine
Xuemei YangZhangxue Hu

Abstract

Recent evidence suggested that angiogenesis played a pivotal role in the development of hepatocellular carcinoma cells (HCC), thus the therapy strategy targeting antiangiogenesis has been regarded as promising method for HCC therapy. Tumor endothelial marker 8 (TEM8) is a recently described protein that is preferentially expressed within tumor endothelium. However, the antiangiogenesis therapy of HCC based on TEM8 has not been reported. In this study, the recombinant adenovirus encoding TEM8 was constructed, and the DCs were transduced with the Ad-TEM8. In addition, the modified DCs were transferred into the BALB/c mice to determine whether DCs transduced with TEM8 could elicit a potent antitumor immunogenic response in vivo. The results demonstrated that DCs transduced with Ad-TEM8 induced specific CTLs effectively, which could secrete IFN-γ and lyse HCC. Furthermore, the modified DCs could effectively protect BALB/c mice from lethal challenges against HCC, reduce tumor growth and increase the mice life span by decreasing tumor vasculature density. These data suggest that the Ad-TEM8 modified DCs may induce antitumor immunity by disrupting tumor vasculature and may thus be used as an efficient therapy strategy to influence tum...Continue Reading

References

Jan 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R S Kerbel
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·J JouanneauJ P Thiery
Aug 19, 2000·Science·B St CroixK W Kinzler
Nov 9, 2001·Nature·K A BradleyJ A Young
Nov 10, 2001·Cytogenetics and Cell Genetics·S LoeperS Urbschat
Oct 3, 2002·Nature Reviews. Cancer·Robert Kerbel, Judah Folkman
Dec 20, 2003·Current Opinion in Oncology·Akash Nanda, Brad St Croix
Apr 6, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Gidon AlmogyAhmed Eid
May 19, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Olivier AdotéviPierre Langlade-Demoyen
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eishiro MizukoshiShuichi Kaneko
Apr 1, 2008·Surgical Oncology Clinics of North America·Travis KidnerYuman Fong
May 26, 2009·Cancer Letters·Tetsuhiro ChibaAtsushi Iwama
Jun 6, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Terence Kin Wah LeeIrene Oi Lin Ng
Jun 23, 2009·Expert Opinion on Drug Delivery·Bei ChenKaichun Wu
Jul 18, 2009·Journal of Immunotherapy·Zhihua RuanYuzhang Wu

❮ Previous
Next ❯

Citations

Feb 3, 2015·Biochimica Et Biophysica Acta·Madelon Q WentinkArjan W Griffioen
Mar 1, 2013·Hepatology International·Iván Lyra-GonzálezJuan Armendáriz-Borunda
Oct 30, 2015·Journal of Translational Medicine·Samuel C WagnerSantosh Kesari
Oct 3, 2017·Biological & Pharmaceutical Bulletin·Tetsuya NomuraNaoki Utoguchi
Oct 18, 2019·PloS One·Kristina PetrovicSteven P Lee
Jul 2, 2014·Molecular Pharmaceutics·Frank KuoElaine M Jagoda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.