PMID: 9658114Jul 11, 1998Paper

Dendritic cells transmit human immunodeficiency virus type 1 to monocytes and monocyte-derived macrophages

Journal of Virology
L KacaniM P Dierich

Abstract

Previous studies have shown that human immunodeficiency virus type 1 (HIV-1) exploits dendritic cells (DC) to replicate and spread among CD4(+) T cells. To explain the predominance of non-syncytium-inducing (NSI) over syncytium-inducing (SI) strains during the initial viremia of HIV, we investigated the ability of blood monocyte (Mo)-derived DC to transmit HIV-1 to CD4(+) cells of the monocytoid lineage. First, we demonstrate that in our system, DC are able to transmit NSI strains, but not SI strains, of HIV-1 to fresh blood Mo and to Mo-derived macrophages (MDM). To establish a productive infection, a 10-fold-lower amount of virus was necessary for DC-mediated transmission of HIV-1 to Mo than in case of cell-free infection. Second, immature CD83(-) DC (imDC) transmit virus to Mo and MDM with higher efficacy compared to mature CD83(+) DC (maDC); this finding is in contrast to data previously obtained with CD4(+) T cells. Third, maturation from imDC to maDC efficiently silenced expression of beta2-integrins CD11b, CD11c, and CD18 by maDC. Moreover, monoclonal antibody against CD18 inhibited transmission of HIV-1 from imDC to Mo. We propose that the adhesion molecules of the CD11/CD18 family, involved in cell-cell interactions of...Continue Reading

References

Jan 1, 1991·Annual Review of Immunology·R M Steinman
Aug 12, 1983·Journal of Immunological Methods·B Freundlich, N Avdalovic
Nov 1, 1995·Immunology Today·G ZambrunoG Girolomoni
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·D WeissmanA S Fauci
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·L J Zhou, T F Tedder
Jun 1, 1996·Immunology Today·J H PetersF Steinbach
Dec 1, 1996·The Journal of Experimental Medicine·A Granelli-PipernoR M Steinman
Feb 1, 1997·Current Opinion in Immunology·M CellaA Lanzavecchia

❮ Previous
Next ❯

Citations

Aug 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·J C Martín, J C Bandrés
Jun 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Colleen M CebullaDaniel D Sedmak
Jun 23, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Salim BounouMichel J Tremblay
Feb 15, 2001·AIDS Research and Human Retroviruses·S A DavidO Narayan
May 9, 2007·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S PerkhoferC Lass-Flörl
Nov 5, 2002·Clinical and Diagnostic Laboratory Immunology·Markus NaglManfred P Dierich
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zsuzsa BajtayManfred P Dierich
Sep 10, 2003·Journal of Leukocyte Biology·Sharon M WahlNancy Vazquez
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L KacaniM P Dierich
Dec 4, 2004·AIDS·Suzanne M Crowe, Birgitta Asjo
Aug 10, 2011·Current Opinion in HIV and AIDS·Georg HuberHeribert Stoiber
Mar 15, 2005·AIDS·Zoltán BánkiHeribert Stoiber
Feb 19, 2003·FEMS Immunology and Medical Microbiology·Cornelia Lass-FlörlReinhard Würzner
Aug 17, 1999·Current Opinion in Immunology·C Reis e SousaP Kaye

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.