Dendritic Cells: Versatile Players in Renal Transplantation.

Frontiers in Immunology
Jinwen LinJianghua Chen

Abstract

Dendritic cells (DCs) induce and regulate adaptive immunity through migrating and maturing in the kidney. In this procedure, they can adopt different phenotypes-rejection-associated DCs promote acute or chronic injury renal grafts while tolerogenic DCs suppress the overwhelmed inflammation preventing damage to renal functionality. All the subsets interact with effector T cells and regulatory T cells (Tregs) stimulated by the ischemia-reperfusion procedure, although the classification corresponding to different effects remains controversial. Thus, in this review, we discuss the origin, maturation, and pathological effects of DCs in the kidney. Then we summarize the roles of divergent DCs in renal transplantation: taking both positive and negative stages in ischemia-reperfusion injury (IRI), switching phenotypes to induce acute or chronic rejection, and orchestrating surface markers for allograft tolerance via alterations in metabolism. In conclusion, we prospect that multidimensional transcriptomic analysis will revolute researches on renal transplantation by addressing the elusive mononuclear phagocyte classification and providing a holistic view of DC ontogeny and subpopulations.

References

Aug 1, 1976·Transplantation·K J LaffertyD W Talmage
Sep 1, 1968·The Journal of Experimental Medicine·R van Furth, Z A Cohn
Jan 1, 1994·Annual Review of Immunology·P Matzinger
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M J GrusbyL H Glimcher
Apr 1, 1998·Nature·J Banchereau, R M Steinman
Dec 8, 1998·The Journal of Experimental Medicine·M RescignoP Ricciardi-Castagnoli
Sep 16, 1999·Pediatric Transplantation·V M DongM H Sayegh
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A W BingamanC P Larsen
Dec 20, 2000·The Journal of Experimental Medicine·J M den HaanM J Bevan
Jan 3, 2001·Nature Medicine·C C Anderson, P Matzinger
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·E J SuchinL A Turka
Feb 24, 2001·The Journal of Experimental Medicine·M V DhodapkarN Bhardwaj
Mar 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C C AndersonP Matzinger
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Geetha ChalasaniFadi G Lakkis
Jun 26, 2002·Kidney International·Roslyn B MannonThomas M Coffman
Oct 23, 2002·The Journal of Experimental Medicine·Gabrielle T BelzWilliam R Heath
Mar 27, 2003·American Journal of Physiology. Renal Physiology·Melissa J Burne-TaneyHamid Rabb
Jan 17, 2004·Blood·Giuseppe CastellanoCees van Kooten
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sharon H JacksonCharles E Egwuagu
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Thilo KrügerChristian Kurts
Mar 3, 2004·European Journal of Immunology·Valérie VerhasseltMichel Goldman
Jul 16, 2004·Kidney International·Dirk K YsebaertMarc E De Broe
Aug 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bethany M TesarDaniel R Goldstein
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Osquel Barroso HerreraRobert I Lechler
Nov 8, 2005·Nature Immunology·Andrew M IntlekoferSteven L Reiner
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jagdeep S ObhraiFadi G Lakkis
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heth R TurnquistAngus W Thomson

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