PMID: 7536248Jan 15, 1995Paper

Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons

The Journal of Physiology
N SprustonB Sakmann

Abstract

1. Properties of dendritic glutamate receptor (GluR) channels were investigated using fast application of glutamate to outside-out membrane patches isolated from the apical dendrites of CA3 and CA1 pyramidal neurons in rat hippocampal slices. CA3 patches were formed (15-76 microns from the soma) in the region of mossy fibre (MF) synapses, and CA1 patches (25-174 microns from the soma) in the region of Schaffer collateral (SC) innervation. 2. Dual-component responses consisting of a rapidly rising and decaying component followed by a second, substantially slower, component were elicited by 1 ms pulses of 1 mM glutamate in the presence of 10 microM glycine and absence of external Mg2+. The fast component was selectively blocked by 2-5 microM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and the slow component by 30 microM D-2-amino-5-phosphonopentanoic acid (D-AP5), suggesting that the fast and slow components were mediated by the GluR channels of the L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and NMDA type, respectively. The peak amplitude ratio of the NMDA to AMPA receptor-mediated components varied between 0.03 and 0.62 in patches from both CA3 and CA1 dendrites. Patches lacking either component were rarely ob...Continue Reading

Citations

Dec 3, 2013·European Journal of Pharmacology·Yuriy Pankratov, Ulyana Lalo
Apr 4, 2009·Journal of Computational Neuroscience·Danielle Morel, William Levy
Dec 12, 2012·Journal of Computational Neuroscience·Keivan MoradiGholamreza Kaka
Dec 7, 2007·Biological cybernetics·C C KerrP A Robinson
Apr 7, 2005·Journal of Cognitive Neuroscience·Gustavo Deco, Edmund T Rolls
Oct 9, 2007·Journal of Cognitive Neuroscience·J P LarssonGustavo Deco
Jun 1, 1996·Current Opinion in Neurobiology·M Frerking, M Wilson
Feb 1, 1997·Experimental Brain Research·C L BernardH Gozlan
May 25, 2004·Neuroscience Research·Ryosuke EnokiHiroyoshi Miyakawa
Mar 11, 2006·The Journal of Physiology·Christine Gebhardt, Stuart G Cull-Candy
Feb 10, 2016·Frontiers in Cellular Neuroscience·Fliza ValiullinaAndrei Rozov
Jun 2, 2000·The Journal of Physiology·S Vicini, G Rumbaugh
May 15, 1997·The Journal of Physiology·M Häusser, A Roth
Oct 23, 1997·The Journal of Physiology·S F Traynelis, P Wahl
Aug 16, 2002·The Journal of Physiology·Donglin BaiJohn C Roder
Nov 13, 2013·The Journal of Physiology·Charlotte Schmidt-SalzmannJosef Bischofberger
Oct 22, 2008·The Journal of Physiology·Richard J Clarke, Jon W Johnson
Oct 13, 2007·The Journal of Physiology·Bogdan A MilojkovicSrdjan D Antic
Aug 14, 2009·The Journal of Physiology·Philippe Ascher, Linda Nowak
Sep 4, 2012·Biochemical and Biophysical Research Communications·Hyun Jae Jang, Jeehyun Kwag
Nov 20, 1997·The Journal of Physiology·J Bischofberger, P Jonas

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