Dendritic growth in the aged human brain and failure of growth in senile dementia

Science
S J Buell, P D Coleman

Abstract

Golgi-stained dendrites of single randomly chosen layer-II pyramidal neurons in the human parahippocampal gyrus were quantified with a computer-microscope system. In nondemented aged cases (average age, 79.6 years), dendritic trees were more extensive than in adult cases (average age, 51.2), with most of the difference resulting from increases in the number and average length of terminal segments of the dendritic tree. These results provide morphological evidence for plasticity in the mature and aged human brain. In senile dementia (average age, 76.0), dendritic trees were less extensive than in adult brains, largely because their terminal segments were fewer and shorter. Cells with shrunken dendritic trees were found in all brains. These data suggest a model of aging in the central nervous system in which one population of neurons dies and regresses and the other survives and grows. The latter appears to be the dominant population in aging without dementia.

References

Jan 1, 1990·Acta Neuropathologica·I Ferrer, F Gullotta
Jan 1, 1994·Acta Neuropathologica·J P Brion, A Résibois
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·R D Lewis, J M Brown
Jan 1, 1990·European Archives of Psychiatry and Clinical Neuroscience·S Sahai
Jun 1, 1991·Human Nature : an Interdisciplinary Biosocial Perspective·L X Blonder
Sep 1, 1989·Aging : Clinical and Experimental Research·Z S Khachaturian
Apr 25, 2009·Acta Neuropathologica·Thomas Arendt
Dec 8, 1980·Brain Research·M MemoM Trabucchi
Feb 1, 1983·Electroencephalography and Clinical Neurophysiology·L A CobenC P Hughes
Jul 7, 1980·Life Sciences·U De Boni, D R McLachlan
Sep 1, 1980·Mechanisms of Ageing and Development·R D Terry
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·J L Haracz
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·T J Teyler, P DiScenna
Mar 1, 1984·Brain Research·T J Teyler, P Discenna
Mar 1, 1984·Brain Research·L E BeckerM M Wood
Nov 1, 1989·Brain Research. Developmental Brain Research·N ZecevicP Rakic
Sep 18, 1992·Brain Research. Developmental Brain Research·A Ruiz-MarcosJ A Muñoz-Cueto
Jun 19, 1992·Brain Research. Developmental Brain Research·L C AngD G Munoz
Sep 1, 1994·Archives of Gerontology and Geriatrics·K Kanda
Feb 1, 1996·Brain Research. Molecular Brain Research·J E CheethamP D Coleman
Jan 1, 1981·Neurobiology of Aging·G Goldman, P D Coleman
Jan 1, 1983·Neurobiology of Aging·C A Curcio, J W Hinds
Jan 1, 1985·Neurobiology of Aging·S W ScheffS T DeKosky
Jul 1, 1986·Neurobiology of Aging·M S LevineJ P McAllister
Mar 1, 1986·Neurobiology of Aging·P D ColemanC A Curcio

Related Concepts

Senile Paranoid Dementia
Golgi Apparatus
Neurons
Brain
Entire Parahippocampal Gyrus
Entire Central Nervous System
Senility
Alzheimer's Disease
Dendritic Tree
Dendrites

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.