Dendritic mRNA targeting and translation

Advances in Experimental Medicine and Biology
Stefan Kindler, Hans-Jürgen Kreienkamp

Abstract

Selective targeting of specific mRNAs into neuronal dendrites and their locally regulated translation at particular cell contact sites contribute to input-specific synaptic plasticity. Thus, individual synapses become decision-making units, which control gene expression in a spatially restricted and nucleus-independent manner. Dendritic targeting of mRNAs is achieved by active, microtubule-dependent transport. For this purpose, mRNAs are packaged into large ribonucleoprotein (RNP) particles containing an array of trans-acting RNA-binding proteins. These are attached to molecular motors, which move their RNP cargo into dendrites. A variety of proteins may be synthesized in dendrites, including signalling and scaffold proteins of the synapse and neurotransmitter receptors. In some cases, such as the alpha subunit of the calcium/calmodulin-dependent protein kinase II (αCaMKII) and the activity-regulated gene of 3.1 kb (Arg3.1, also referred to as activity-regulated cDNA, Arc), their local synthesis at synapses can modulate long-term changes in synaptic efficiency. Local dendritic translation is regulated by several signalling cascades including Akt/mTOR and Erk/MAP kinase pathways, which are triggered by synaptic activity. More re...Continue Reading

Citations

Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jociane de Carvalho MyskiwIván Izquierdo
Aug 30, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vera HapiakRichard Komuniecki
Jan 29, 2014·Molecular & Cellular Proteomics : MCP·Md Mahiuddin AhmedKatheleen J Gardiner
Jun 25, 2016·Nature Reviews. Neurology·Peter B Crino
Sep 1, 2013·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·M G BelekhovaN B Kenigfest
Oct 12, 2012·Brain Structure & Function·María Eugenia Cornide-PetronioMaría Celina Rodicio
Aug 10, 2013·Developmental Neurobiology·Rotem B Perry, Mike Fainzilber
Aug 21, 2013·Developmental Neurobiology·Laura F GumyCasper C Hoogenraad
Aug 23, 2018·Archives of Toxicology·Kimberly P KeilPamela J Lein
Mar 23, 2019·Frontiers in Genetics·Sarah C Hughes, Andrew J Simmonds
Nov 6, 2012·Journal of Neurochemistry·Krishna H ZivrajStefan Kindler
Nov 20, 2016·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·M McCoyF Corbin
Jun 7, 2018·Cell Metabolism·Mark P Mattson, Thiruma V Arumugam
Jul 13, 2021·Frontiers in Cellular Neuroscience·Andres Di PaoloJosé Roberto Sotelo-Silveira
Jul 3, 2021·Cell Biochemistry and Function·Anna S Voronina, Elena S Pshennikova

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Huidong Wang, Henri Tiedge
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Nobutaka Hirokawa
Genesis : the Journal of Genetics and Development
Matthew A Callan, Daniela C Zarnescu
Proceedings of the National Academy of Sciences of the United States of America
Oswald Steward, Paul Worley
© 2022 Meta ULC. All rights reserved