Dendritic nicotinic receptors modulate backpropagating action potentials and long-term plasticity of interneurons

The European Journal of Neuroscience
Balázs RózsaE Sylvester Vizi

Abstract

Stratum radiatum interneurons, unlike pyramidal cells, are rich in nicotinic acetylcholine receptors (nAChRs); however, the role of these receptors in plasticity has remained elusive. As opposed to previous physiological studies, we found that functional alpha7-subunit-containing nAChRs (alpha7-nAChRs) are abundant on interneuron dendrites of rats. Moreover, dendritic Ca2+ transients induced by activation of alpha7-nAChRs increase as a function of distance from soma. The activation of these extrasynaptic alpha7-nAChRs by cholinergic agonists either facilitated or depressed backpropagating action potentials, depending on the timing of alpha7-nAChR activation. We have previously shown that dendritic alpha7-nAChRs are involved in the regulation of synaptic transmission, suggesting that alpha7-nAChRs may play an important role in the regulation of the spike timing-dependent plasticity. Here we provide evidence that long-term potentiation is indeed boosted by stimulation of dendritic alpha7-nAChRs. Our results suggest a new mechanism for a cholinergic switch in memory encoding and retrieval.

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Citations

Dec 17, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nivethida ThirugnanasambandamMichael A Nitsche
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iris OrenKarri P Lamsa
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David Gómez-VarelaDarwin K Berg
Nov 12, 2013·Neural Computation·Aurel A Lazar, Yevgeniy B Slutskiy
Feb 4, 2014·Neuropharmacology·Krisztina PestiE Sylvester Vizi
Nov 30, 2011·The Journal of Physiology·Marilena Griguoli, Enrico Cherubini
Nov 28, 2012·Brain Research Bulletin·Balázs LendvaiZsolt Némethy
Jan 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Gergely KatonaBalázs Rózsa
Nov 22, 2014·Frontiers in Synaptic Neuroscience·Francisco J Barrantes

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