Dendritic plasticity of CA1 pyramidal neurons after transient global ischemia

Neuroscience
Y-W RuanZ C Xu

Abstract

Dendrites and spines undergo dynamic changes in physiological conditions, such as learning and memory, and in pathological conditions, such as Alzheimer's disease and epilepsy. Long-term dendritic plasticity has also been reported after ischemia/hypoxia, which might be compensatory effects of surviving neurons for the functional recovery after the insults. However, the dendritic changes shortly after ischemia, which might be associated with the pathogenesis of ischemic cell death, remain largely unknown. To reveal the morphological changes of ischemia-vulnerable neurons after ischemia, the present study investigated the alteration of dendritic arborization of CA1 pyramidal neurons in rats after transient cerebral ischemia using intracellular staining technique in vivo. The general appearance of dendritic arborization of CA1 neurons within 48 h after ischemia was similar to that of control neurons. However, a dramatic increase of dendritic disorientation was observed after ischemia with many basal dendrites coursed into the territory of apical dendrites and apical dendrites branched into the region of basal dendrites. In addition, a significant increase of apical dendritic length was found 24 h after ischemia. The increase of de...Continue Reading

References

May 1, 1979·Stroke; a Journal of Cerebral Circulation·W A Pulsinelli, J B Brierley
Jun 19, 1992·Brain Research. Developmental Brain Research·N A Rashid, M A Cambray-Deakin
Mar 20, 1992·Brain Research. Developmental Brain Research·M A Cambray-Deakin, R D Burgoyne
May 22, 1990·The Journal of Comparative Neurology·N IshizukaD G Amaral
Aug 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·M YamadaM Hayakawa
Feb 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W BodschK A Hossmann
May 1, 1982·Annals of Neurology·W A PulsinelliF Plum
Sep 11, 1995·The Journal of Comparative Neurology·N J Bannister, A U Larkman
Oct 1, 1994·Journal of Neuroscience Research·G MorfiniA Cáceres
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M MüllerS M Thompson
Jan 8, 1994·The Journal of Comparative Neurology·X G LiG Buzsáki
Nov 6, 1995·The Journal of Comparative Neurology·N IshizukaD G Amaral
Feb 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R R NuijtinckM T Mud
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·E S LevineM R Plummer
Apr 27, 2004·Trends in Neurosciences·Mayank R Mehta
Jun 11, 2004·Nature·Masanori MatsuzakiHaruo Kasai
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Li-Jen LeeReha S Erzurumlu

❮ Previous
Next ❯

Citations

Apr 16, 2011·Development, Growth & Differentiation·Kazuo Emoto
Mar 24, 2007·Annual Review of Neuroscience·Jay Z ParrishYuh Nung Jan
May 21, 2010·PLoS Computational Biology·Ronald A J van Elburg, Arjen van Ooyen
Sep 8, 2010·Neurochemistry International·Gutiérrez-Vargas JohannaCardona-Gómez Gloria Patricia
Jun 19, 2008·Experimental Neurology·Yuan FanPaul E Schulz
Mar 7, 2008·Behavioural Brain Research·Panchanan MaitiShashi B Singh
Nov 1, 2006·Journal of Neuroscience Research·Yi-Wen RuanZao C Xu
Jan 16, 2008·Journal of Pineal Research·Miguel CervantesGraciela Letechipía-Vallejo
Oct 4, 2006·Neural Networks : the Official Journal of the International Neural Network Society·Markus ButzGertraud Teuchert-Noodt
Mar 1, 2014·Developmental Cell·Julia C GeigerAmparo Acker-Palmer
Jun 22, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ewa Jakubowska-DogruSinan Yürüker
Apr 4, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert M DietzPaco S Herson
Jan 16, 2008·Physiological Reviews·Tihomir Paul Obrenovitch
Apr 30, 2017·Journal of Alzheimer's Disease : JAD·Holly M Stradecki-CohanMiguel A Perez-Pinzon
Feb 2, 2021·Frontiers in Neuroscience·Zhongshan ShiZao C Xu
May 7, 2021·Journal of Nutritional Science and Vitaminology·Ryota IwaiKen-Ichi Mizuatni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.