Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats

Molecular and Cellular Neurosciences
Miranda C StaplesChitra D Mandyam

Abstract

Prolonged alcohol exposure has been previously shown to impair the structure and function of the hippocampus, although the underlying structural and biochemical alterations contributing to these deleterious effects are unclear. Also unclear is whether these changes persist into prolonged periods of abstinence. Previous work from our lab utilizing a clinically relevant rodent model of alcohol consumption demonstrated that alcohol dependence (induced by chronic intermittent ethanol vapor exposure or CIE) decreases proliferation and survival of neural stem cells in the hippocampal subgranular zone and hippocampal neurogenesis in the dentate gyrus, implicating this region of the cortex as particularly sensitive to the toxic effects of prolonged ethanol exposure. For this study, we investigated seven weeks of CIE-induced morphological changes (dendritic complexity and dendritic spine density) of dentate gyrus (DG) granule cell neurons, CA3, and CA1 pyramidal neurons and the associated alterations in biochemical markers of synaptic plasticity and toxicity (NMDA receptors and PSD-95) in the hippocampus in ethanol-experienced Wistar rats 3h (CIE) and 21days (protracted abstinence) after the last ethanol vapor exposure. CIE reduced dend...Continue Reading

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Citations

Feb 3, 2016·Frontiers in Neuroscience·María Llorens-MartínJesús Ávila
Dec 22, 2015·Addiction Biology·Anna K RadkeAndrew Holmes
Dec 1, 2015·Frontiers in Cellular Neuroscience·Paolo FollesaGiorgio Gorini
Jun 4, 2016·Cellular and Molecular Neurobiology·Yongjun SunZibin Gao
Mar 24, 2018·Addiction Biology·Zhe ShiHuanxing Su
Aug 23, 2020·Brain Sciences·Lauren C Smith, Adam Kimbrough
Aug 24, 2017·Alcoholism, Clinical and Experimental Research·Adam KimbroughOlivier George
Feb 11, 2020·Frontiers in Behavioral Neuroscience·Rodrigo G MiraWaldo Cerpa
Jun 25, 2020·International Journal of Molecular Sciences·Muhammad Sona KhanChitra D Mandyam
Sep 9, 2021·Journal of Neuroscience Research·Miranda C StaplesChitra D Mandyam

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